There were 12 games for Mississippi softball on Wed, 4/22/2026. The featured games were by Mississippi top ranked teams Oxford (MS) vs. #2 DeSoto Central (Southaven, MS), and Louisville (MS) @ #7 Itawamba Agricultural (Fulton, MS). The first game, Columbia (MS) @ #8 West Lauderdale (Collinsville, MS), started at 5p.
