| 1 | Brandon WegherRB, DBBHCHS (Sioux City) | 2334 | 179.5 | 8.16 | 286 | 95 | 31 | 0 | 13 |
| 2 | Walker WoodsRB, DBWaukee | 1562 | 156.2 | 5.98 | 261 | 66 | 18 | 2 | 10 |
| 3 | Jeff WoodyRBSPHS (Pleasant Hill) | 1555 | 141.4 | 8.02 | 194 | 80 | 16 | 2 | 11 |
| 4 | Wade RaymondRB, CBGMG (Garwin) | 1251 | 139.0 | 6.32 | 198 | 80 | 11 | 0 | 9 |
| 5 | Andre DawsonWashington (Cedar Rapids) | 1085 | 120.6 | 7.48 | 145 | 24 | 11 | 0 | 9 |
| 6 | Seth ThomasRB, OLBBedford | 1047 | 104.7 | 6.50 | 161 | 35 | 10 | 0 | 10 |
| 7 | Kyle WilkeningRB, LBPekin (Packwood) | 1014 | 92.2 | 5.76 | 176 | 41 | 6 | 0 | 11 |
| 8 | Dj BennettRB, DBCGHS (Clarion) | 964 | 107.1 | 6.43 | 150 | 0 | 10 | 0 | 9 |
| 9 | Grant MayfieldRB, DBDCHS (West Des Moines) | 921 | 115.1 | 6.77 | 136 | 72 | 13 | 0 | 8 |
| 10 | Grant DegenQB, DBWest Sioux (Hawarden) | 896 | 99.6 | 5.71 | 157 | 65 | 11 | 4 | 9 |
| 11 | Justin WarnerRB, DBDCHS (West Des Moines) | 893 | 99.2 | 7.20 | 124 | 45 | 10 | 0 | 9 |
| 12 | Matt MercerB, DBWest Branch | 832 | 92.4 | 6.88 | 121 | 36 | 15 | 0 | 9 |
| 13 | Michael PerdewRB, CBBedford | 820 | 82.0 | 7.66 | 107 | 95 | 9 | 4 | 10 |
| 14 | Chance ChilcoteHB, FSHudson | 808 | 101.0 | 5.42 | 149 | 0 | 5 | 0 | 8 |
| 15 | Jim CherryRB, DBEagle Grove | 773 | 77.3 | 6.84 | 113 | 59 | 9 | 6 | 10 |
| 16 | Michael AlcarezRBSCNHS (Sioux City) | 748 | 93.5 | 7.71 | 97 | 0 | 9 | 0 | 8 |
| 17 | Colin McKeonRB, LBEast Buchanan (Winthrop) | 660 | 73.3 | 4.85 | 136 | 48 | 7 | 0 | 9 |
| 18 | Tim JohnsonKennedy (Cedar Rapids) | 627 | 89.6 | 6.15 | 102 | 0 | 4 | 0 | 7 |
| 19 | Jordan ThompsonB, DBWest Branch | 623 | 69.2 | 4.72 | 132 | 22 | 6 | 0 | 9 |
| 20 | Tyler CrouseRB, DEPekin (Packwood) | 603 | 67.0 | 6.55 | 92 | 45 | 9 | 0 | 9 |
| 21 | Zach PloegerQB, SEEagle Grove | 600 | 60.0 | 5.08 | 118 | 53 | 9 | 9 | 10 |
| 22 | Jon MorrisWB, DBEagle Grove | 553 | 55.3 | 9.07 | 61 | 58 | 9 | 2 | 10 |
| 23 | Marcus JamesQB, DBSCNHS (Sioux City) | 528 | 66.0 | 5.62 | 94 | 0 | 8 | 0 | 8 |
| 24 | Ben LubbenRB, CBCentral Clinton (DeWitt) | 490 | 61.2 | 7.78 | 63 | 63 | 13 | 0 | 8 |
| 25 | Anthony TomschaRB, DBSCNHS (Sioux City) | 490 | 98.0 | 6.05 | 81 | 0 | 6 | 0 | 5 |
| 26 | Josh FolchertRB, DBSCNHS (Sioux City) | 482 | 60.2 | 9.45 | 51 | 0 | 8 | 0 | 8 |
| 27 | Jay MorrisQB, DBWest Harrison (Mondamin) | 480 | 53.3 | 5.00 | 96 | 47 | 2 | 0 | 9 |
| 28 | Dan WielandEast Buchanan (Winthrop) | 461 | 51.2 | 4.43 | 104 | 0 | 6 | 0 | 9 |
| 29 | Collin StyronHB, DBWaterloo West (Waterloo) | 459 | 51.0 | 4.37 | 105 | 52 | 3 | 1 | 9 |
| 30 | Levi KeleherRBLawton-Bronson (Lawton) | 447 | 111.8 | 7.45 | 60 | 0 | 5 | 0 | 4 |
| 31 | Jake KnottRB, LBWaukee | 441 | 49.0 | 6.89 | 64 | 38 | 4 | 0 | 9 |
| 32 | Gary EwartRB, OLBBedford | 440 | 48.9 | 4.84 | 91 | 38 | 4 | 3 | 9 |
| 33 | Greg OldsenRB, MLBCentral Clinton (DeWitt) | 426 | 53.2 | 6.98 | 61 | 37 | 1 | 0 | 8 |
| 34 | Harrison WilliamsRBSPHS (Pleasant Hill) | 397 | 49.6 | 5.36 | 74 | 58 | 5 | 0 | 8 |
| 35 | Adam MartinRB, LBPekin (Packwood) | 395 | 35.9 | 5.90 | 67 | 37 | 2 | 0 | 11 |
| 36 | Eric KistWB, SEagle Grove | 393 | 39.3 | 6.78 | 58 | 36 | 7 | 2 | 10 |
| 37 | Donterrious PorterHB, DBWaterloo West (Waterloo) | 385 | 42.8 | 3.74 | 103 | 30 | 0 | 0 | 9 |
| 38 | Holden WaltonRB, LBCGHS (Clarion) | 368 | 40.9 | 4.14 | 89 | 0 | 3 | 1 | 9 |
| 39 | Josh Van WykFB, LBLynnville-Sully (Sully) | 348 | 38.7 | 2.83 | 123 | 44 | 0 | 8 | 9 |
| 40 | Jared WoldRB, KRCentral Clinton (DeWitt) | 339 | 42.4 | 7.70 | 44 | 29 | 6 | 1 | 8 |
| 41 | Ryan EdwardsQB, KWaterloo West (Waterloo) | 338 | 37.6 | 3.10 | 109 | 55 | 12 | 4 | 9 |
| 42 | Mike RipkeRB, FSSCHS (Sioux Rapids) | 332 | 47.4 | 4.74 | 70 | 43 | 2 | 0 | 7 |
| 43 | Tyler BookRB, LBPekin (Packwood) | 310 | 28.2 | 5.64 | 55 | 33 | 6 | 0 | 11 |
| 44 | Ethan AndersonRB, DBCGHS (Clarion) | 309 | 34.3 | 6.44 | 48 | 0 | 6 | 1 | 9 |
| 45 | Dane AskelsenRB, DLCGHS (Clarion) | 276 | 30.7 | 4.06 | 68 | 0 | 2 | 0 | 9 |
| 46 | Wyatt SuessDB, QBWashington (Cedar Rapids) | 266 | 29.6 | 5.22 | 51 | 0 | 2 | 1 | 9 |
| 47 | Kris PorterRB, LBWest Sioux (Hawarden) | 260 | 65.0 | 6.05 | 43 | 54 | 1 | 1 | 4 |
| 48 | Edwin ArceoWR, DBMuscatine | 259 | 32.4 | 8.63 | 30 | 78 | 3 | 0 | 8 |
| 49 | Jonothon LopezRB, DBWest Sioux (Hawarden) | 251 | 27.9 | 6.12 | 41 | 48 | 1 | 0 | 9 |
| 50 | Joe ZhissEast Buchanan (Winthrop) | 250 | 27.8 | 3.91 | 64 | 0 | 3 | 0 | 9 |