| 1 | Zach MillsFB, SSDelta (Muncie) | 2424 | 186.5 | 7.58 | 320 | 77 | 28 | 0 | 13 |
| 2 | Kiante EnisRB, DBWCHS (Winchester) | 2393 | 184.1 | 8.61 | 278 | 85 | 35 | 2 | 13 |
| 3 | Travis RolleRB, WRWest Lafayette | 2379 | 158.6 | 6.12 | 389 | 74 | 27 | 0 | 15 |
| 4 | Jackson AnthropRB, FSLCCHS (Lafayette) | 2247 | 149.8 | 8.95 | 251 | 80 | 43 | 1 | 15 |
| 5 | Alex NelighQB, LBNew Palestine | 2097 | 149.8 | 8.49 | 247 | 55 | 37 | 0 | 14 |
| 6 | Austin KoppRB, OLBCorydon Central (Corydon) | 2083 | 189.4 | 9.87 | 211 | 69 | 31 | 2 | 11 |
| 7 | Will JonesRB, FSLapel | 2032 | 203.2 | 8.13 | 250 | 72 | 23 | 1 | 10 |
| 8 | Isaac JamesATH, RBLowell | 1931 | 148.5 | 5.56 | 347 | 75 | 28 | 3 | 13 |
| 9 | Titus MccoyRBCenter Grove (Greenwood) | 1912 | 136.6 | 6.40 | 299 | 0 | 28 | 1 | 14 |
| 10 | Andre WellsRB, DEMuncie Central (Muncie) | 1907 | 190.7 | 9.68 | 197 | 90 | 14 | 2 | 10 |
| 11 | Mitchell VanbrocklinRB, DLWoodlan (Woodburn) | 1896 | 135.4 | 5.80 | 327 | 74 | 22 | 0 | 14 |
| 12 | Gabe ColemanRB, CBIBCHS (Indianapolis) | 1887 | 134.8 | 5.58 | 338 | 65 | 16 | 3 | 14 |
| 13 | Amaun ClarkRB, CBFWBD (Fort Wayne) | 1859 | 123.9 | 7.29 | 255 | 0 | 25 | 2 | 15 |
| 14 | Caden FieldsMLB, RBNorth Knox (Bicknell) | 1839 | 183.9 | 7.10 | 259 | 60 | 16 | 2 | 10 |
| 15 | Jeff GrahamQB, FSEGHS (Bloomfield) | 1838 | 167.1 | 8.75 | 210 | 73 | 21 | 5 | 11 |
| 16 | Joel DurkesFB, MLBOak Hill (Converse) | 1834 | 203.8 | 6.97 | 263 | 0 | 24 | 3 | 9 |
| 17 | Ben BertschWR, CBCCLHS (Cambridge City) | 1814 | 151.2 | 5.89 | 308 | 0 | 18 | 0 | 12 |
| 18 | Jeron GrayRB, CBKokomo | 1813 | 139.5 | 7.72 | 235 | 83 | 24 | 3 | 13 |
| 19 | Steven O'nealWR, RBColumbus East (Columbus) | 1798 | 163.5 | 9.13 | 197 | 89 | 22 | 0 | 11 |
| 20 | Landon HarrisRB, MLBChurubusco | 1789 | 162.6 | 8.17 | 219 | 80 | 21 | 0 | 11 |
| 21 | Jacob EarlRBNorth Vermillion (Cayuga) | 1788 | 149.0 | 10.84 | 165 | 77 | 35 | 0 | 12 |
| 22 | Garrett ElderQB, DBWhitko (South Whitley) | 1784 | 148.7 | 9.64 | 185 | 92 | 23 | 0 | 12 |
| 23 | Kyle ShafferFB, OLBSPHS (Greencastle) | 1771 | 147.6 | 6.63 | 267 | 71 | 26 | 0 | 12 |
| 24 | Camdon CartwrightRB, DBBoonville | 1770 | 160.9 | 8.35 | 212 | 77 | 20 | 10 | 11 |
| 25 | Mitchell BurtonRB, DBColumbus North (Columbus) | 1757 | 175.7 | 7.48 | 235 | 91 | 22 | 2 | 10 |
| 26 | Jake WilsonTB, FSElwood | 1755 | 159.5 | 6.57 | 267 | 79 | 15 | 0 | 11 |
| 27 | Luke PattonQB, CBEast Central (St. Leon) | 1712 | 122.3 | 6.69 | 256 | 75 | 33 | 4 | 14 |
| 28 | Gerrid DoaksRB, SBLCHS (Indianapolis) | 1705 | 170.5 | 7.97 | 214 | 77 | 22 | 5 | 10 |
| 29 | Matt ShorterWinamac | 1698 | 154.4 | 7.82 | 217 | 97 | 17 | 3 | 11 |
| 30 | Sam SchoonveldRB, OLBCPHS (Frankfort) | 1668 | 139.0 | 6.18 | 270 | 87 | 14 | 4 | 12 |
| 31 | Aaron WilsonRB, LBCKHS (Indianapolis) | 1654 | 127.2 | 10.60 | 156 | 67 | 14 | 0 | 13 |
| 32 | Nick BrickensRB, DBNew Palestine | 1627 | 116.2 | 9.57 | 170 | 81 | 20 | 0 | 14 |
| 33 | Isaiah DelphFrankton | 1622 | 162.2 | 7.02 | 231 | 89 | 21 | 3 | 10 |
| 34 | Sam BestRB, MLBNorth Harrison (Ramsey) | 1621 | 162.1 | 6.09 | 266 | 0 | 23 | 0 | 10 |
| 35 | Jacob BrownPioneer (Royal Center) | 1613 | 124.1 | 10.08 | 160 | 69 | 22 | 2 | 13 |
| 36 | Jaden BakerGarrett | 1587 | 132.2 | 6.50 | 244 | 45 | 14 | 1 | 12 |
| 37 | Joe BichlerRB, SSPrinceton | 1583 | 131.9 | 7.68 | 206 | 64 | 19 | 3 | 12 |
| 38 | Cole MccrearyRB, MLBFCHS (Brookville) | 1581 | 158.1 | 4.79 | 330 | 51 | 17 | 4 | 10 |
| 39 | Eli WallaceRB, OLBLakeland (LaGrange) | 1557 | 141.5 | 7.11 | 219 | 0 | 24 | 2 | 11 |
| 40 | Keezan JarrardTE, DEEastside (Butler) | 1531 | 139.2 | 7.89 | 194 | 83 | 22 | 0 | 11 |
| 41 | Trevor KennardRB, OLBMt. Carmel | 1488 | 165.3 | 7.19 | 207 | 0 | 22 | 0 | 9 |
| 42 | Wesley CookRBTWHHS (Lizton) | 1487 | 123.9 | 8.40 | 177 | 84 | 27 | 0 | 12 |
| 43 | Drayke RichardtRB, DBEMDHS (Evansville) | 1486 | 123.8 | 7.66 | 194 | 69 | 30 | 3 | 12 |
| 44 | Deshaun FrenchRBShelbyville | 1448 | 131.6 | 7.66 | 189 | 78 | 18 | 3 | 11 |
| 45 | O'brien SelbyRB, WRSVHS (French Lick) | 1442 | 206.0 | 8.24 | 175 | 0 | 15 | 0 | 7 |
| 46 | Doug RosemeyerFB, RBEast Central (St. Leon) | 1442 | 103.0 | 7.10 | 203 | 70 | 14 | 6 | 14 |
| 47 | Dalton HatcherRB, CBShenandoah (Middletown) | 1440 | 144.0 | 10.51 | 137 | 94 | 17 | 0 | 10 |
| 48 | Kobe FowlerRB, LBCalumet New Tech (Gary) | 1433 | 143.3 | 5.39 | 266 | 83 | 13 | 0 | 10 |
| 49 | Jacob JonesRBSpeedway | 1430 | 130.0 | 8.31 | 172 | 0 | 15 | 3 | 11 |
| 50 | Dillon SmithRB, OLBTri-Central (Sharpsville) | 1410 | 128.2 | 7.05 | 200 | 46 | 10 | 0 | 11 |