| 1 | Pat CashmoreRB, LBSt. Pius X (Kansas City) | 2202 | 169.4 | 8.84 | 249 | 0 | 39 | 0 | 13 |
| 2 | Ethan HarrisRB, OLBSouth Shelby (Shelbina) | 2045 | 146.1 | 9.98 | 205 | 82 | 31 | 0 | 14 |
| 3 | Montee BallRB, LBTimberland (Wentzville) | 1845 | 184.5 | 6.21 | 297 | 0 | 15 | 0 | 10 |
| 4 | Clifton BrownRB, FSSt. Charles | 1757 | 175.7 | 7.32 | 240 | 0 | 14 | 0 | 10 |
| 5 | Mike HallRB, SLutheran (St. Peters) | 1756 | 175.6 | 5.76 | 305 | 0 | 12 | 0 | 10 |
| 6 | Caleb SandersRB, DBCarthage | 1753 | 194.8 | 9.74 | 180 | 96 | 30 | 0 | 9 |
| 7 | Rayon SimmonsRBCBCHS (St. Louis) | 1664 | 166.4 | 8.67 | 192 | 0 | 22 | 0 | 10 |
| 8 | Chance DavisRB, OLBAva | 1633 | 148.5 | 6.58 | 248 | 0 | 21 | 0 | 11 |
| 9 | Aaron O'LaughlinRB, FSSouth Shelby (Shelbina) | 1631 | 125.5 | 8.72 | 187 | 76 | 20 | 0 | 13 |
| 10 | Devion MooreRB, CBHCHS (Florissant) | 1591 | 159.1 | 7.72 | 206 | 0 | 18 | 0 | 10 |
| 11 | Carlos AndersonRBBlue Springs | 1590 | 144.5 | 7.13 | 223 | 0 | 22 | 0 | 11 |
| 12 | Conrad HooperLB, RBOdessa | 1576 | 157.6 | 6.59 | 239 | 0 | 15 | 0 | 10 |
| 13 | Cody DerousseRB, DBCrystal City | 1566 | 142.4 | 9.61 | 163 | 0 | 20 | 0 | 11 |
| 14 | Brian ElkinsCassville | 1542 | 154.2 | 6.95 | 222 | 0 | 23 | 0 | 10 |
| 15 | Mike BuntonFB, LBParkway North (St. Louis) | 1533 | 127.8 | 7.98 | 192 | 89 | 21 | 0 | 12 |
| 16 | Ronnie WingoRB, DBSLU (St. Louis) | 1475 | 134.1 | 5.27 | 280 | 0 | 7 | 0 | 11 |
| 17 | Steve WaldronRB, SKennedy (Manchester) | 1415 | 141.5 | 8.79 | 161 | 0 | 12 | 0 | 10 |
| 18 | Tim ClarkRB, DBCCP (St. Louis) | 1381 | 138.1 | 6.90 | 200 | 0 | 15 | 0 | 10 |
| 19 | Ben PritchettBelton | 1381 | 153.4 | 6.90 | 200 | 62 | 21 | 0 | 9 |
| 20 | Nick BaerRB, DBSeckman (Imperial) | 1368 | 136.8 | 7.20 | 190 | 0 | 18 | 0 | 10 |
| 21 | Previn PerryTB, LBLNHS (St. Louis) | 1317 | 109.8 | 7.36 | 179 | 0 | 14 | 0 | 12 |
| 22 | Kaleb LakeMarceline | 1317 | 131.7 | 6.33 | 208 | 0 | 0 | 0 | 10 |
| 23 | Matt EspeyTB, FSFZNHS (O'Fallon) | 1301 | 130.1 | 6.26 | 208 | 0 | 12 | 0 | 10 |
| 24 | Nick PollardRB, DBEast Newton (Granby) | 1301 | 130.1 | 5.83 | 223 | 0 | 14 | 0 | 10 |
| 25 | Steve MayRB, FSParkway West (Ballwin) | 1286 | 116.9 | 6.34 | 203 | 0 | 17 | 0 | 11 |
| 26 | A.j. BuxtonRB, DBRockwood Summit (Fenton) | 1281 | 106.8 | 6.19 | 207 | 0 | 12 | 0 | 12 |
| 27 | Sean RansburgQB, DBHarrisonville | 1281 | 91.5 | 6.19 | 207 | 87 | 24 | 0 | 14 |
| 28 | GowerWarrensburg | 1254 | 125.4 | 6.89 | 182 | 78 | 11 | 0 | 10 |
| 29 | Trent BrewerRB, LBPCHS (Chesterfield) | 1253 | 125.3 | 6.49 | 193 | 0 | 15 | 0 | 10 |
| 30 | Jacob McKinleyRB, DBParkway North (St. Louis) | 1227 | 102.2 | 5.63 | 218 | 55 | 14 | 0 | 12 |
| 31 | Chad KilgoreRB, LBExcelsior Springs | 1212 | 121.2 | 5.39 | 225 | 0 | 16 | 0 | 10 |
| 32 | Brayden PayneRB, DBBolivar | 1200 | 120.0 | 5.50 | 218 | 0 | 10 | 0 | 10 |
| 33 | Pierre DesirWR, DBHCHS (St. Charles) | 1192 | 108.4 | 10.10 | 118 | 0 | 24 | 0 | 11 |
| 34 | Greg GraflageRB, LBKennedy (Manchester) | 1191 | 119.1 | 7.40 | 161 | 0 | 13 | 0 | 10 |
| 35 | Thomas MerriweatherTB, LBHEHS (St. Louis) | 1163 | 116.3 | 7.46 | 156 | 0 | 14 | 0 | 10 |
| 36 | Evan MoffisRB, LBWest Plains | 1146 | 114.6 | 5.33 | 215 | 61 | 13 | 0 | 10 |
| 37 | Quintin MorrisFB, LBNormandy (St. Louis) | 1117 | 111.7 | 6.04 | 185 | 0 | 0 | 0 | 10 |
| 38 | Ricky HicksRB, OLBCentral (Kansas City) | 1108 | 123.1 | 7.75 | 143 | 80 | 8 | 0 | 9 |
| 39 | Jake VonderbrueggeRB, DBHillsboro | 1104 | 110.4 | 6.73 | 164 | 0 | 8 | 0 | 10 |
| 40 | Collin HowardQB, DBWebb City | 1103 | 78.8 | 7.12 | 155 | 60 | 19 | 0 | 14 |
| 41 | Kevin SchniedersRB, DBPotosi | 1098 | 109.8 | 7.62 | 144 | 0 | 13 | 0 | 10 |
| 42 | Denodus O'BryantRB, SSWashington | 1096 | 109.6 | 7.40 | 148 | 0 | 15 | 0 | 10 |
| 43 | Antonio TullockRB, DBFestus | 1096 | 137.0 | 6.76 | 162 | 71 | 11 | 0 | 8 |
| 44 | Deandre FosterFB, DECentral (Kansas City) | 1087 | 120.8 | 7.34 | 148 | 66 | 7 | 0 | 9 |
| 45 | A.j. StewardQB, LBRGHS (St. Louis) | 1087 | 108.7 | 6.18 | 176 | 0 | 0 | 0 | 10 |
| 46 | Danny JamesRB, LBCrystal City | 1074 | 97.6 | 9.85 | 109 | 0 | 13 | 0 | 11 |
| 47 | Quartize JacksonRB, DBMCNHS (Florissant) | 1068 | 89.0 | 6.14 | 174 | 0 | 16 | 0 | 12 |
| 48 | David PenwellLB, RBFredericktown | 1060 | 106.0 | 6.54 | 162 | 0 | 11 | 0 | 10 |
| 49 | Dennis HutchingsRB, LBHolden | 1056 | 105.6 | 7.09 | 149 | 0 | 11 | 0 | 10 |
| 50 | Stephen WoodRB, LBGallatin | 1054 | 117.1 | 10.04 | 105 | 16 | 19 | 0 | 9 |