| 1 | Kellen OverstreetRB, SPenney (Hamilton) | 4259 | 304.2 | 10.62 | 401 | 84 | 65 | 3 | 14 |
| 2 | Hunter YearganRB, OLBWillard | 2689 | 298.8 | 7.84 | 343 | 79 | 52 | 1 | 9 |
| 3 | Zane JacobyQB, DBWestran (Huntsville) | 2551 | 170.1 | 10.20 | 250 | 98 | 43 | 2 | 15 |
| 4 | Josh MartinRB, MLBCamdenton | 2506 | 227.8 | 7.14 | 351 | 73 | 28 | 3 | 11 |
| 5 | Trace WindsorRB, DBSouth Shelby (Shelbina) | 2477 | 190.5 | 9.99 | 248 | 82 | 29 | 1 | 13 |
| 6 | Bryce JeffersonRB, SSLutheran (St. Peters) | 2303 | 230.3 | 9.84 | 234 | 97 | 32 | 0 | 10 |
| 7 | Charlie NihartRB, LBSmithville | 2272 | 189.3 | 7.57 | 300 | 71 | 22 | 5 | 12 |
| 8 | J.j. RiversRB, CBVan Horn (Independence) | 2214 | 246.0 | 10.11 | 219 | 90 | 22 | 0 | 9 |
| 9 | Tony GrantRB, MLBKickapoo (Springfield) | 1950 | 177.3 | 6.44 | 303 | 80 | 28 | 1 | 11 |
| 10 | Keynan ScheurichRB, DBCarl Junction | 1778 | 161.6 | 9.07 | 196 | 76 | 31 | 1 | 11 |
| 11 | Reagan FrakesRB, MLBKearney | 1769 | 126.4 | 5.44 | 325 | 0 | 26 | 2 | 14 |
| 12 | Anthony Riley jrRBParkview (Springfield) | 1748 | 145.7 | 5.87 | 298 | 65 | 26 | 8 | 12 |
| 13 | Bryan PorterRB, LBLiberty (Mountain View) | 1694 | 141.2 | 7.18 | 236 | 74 | 30 | 0 | 12 |
| 14 | Makenna CookQB, OLBKirksville | 1672 | 167.2 | 6.46 | 259 | 65 | 16 | 5 | 10 |
| 15 | Driston SelfQB, FSOsceola | 1537 | 128.1 | 8.31 | 185 | 89 | 21 | 0 | 12 |
| 16 | Dalton TaylorRB, WRStrafford | 1529 | 117.6 | 9.80 | 156 | 76 | 35 | 0 | 13 |
| 17 | Jordan SalimaRB, FSTruman (Independence) | 1508 | 137.1 | 6.23 | 242 | 0 | 16 | 2 | 11 |
| 18 | Adam NorsworthyRB, DBJoplin | 1501 | 150.1 | 6.20 | 242 | 80 | 13 | 4 | 10 |
| 19 | Brandon ThoennesRBCole Camp | 1498 | 136.2 | 7.34 | 204 | 75 | 24 | 3 | 11 |
| 20 | David RobinsonRB, DBUAC (Kansas City) | 1457 | 145.7 | 7.40 | 197 | 80 | 15 | 0 | 10 |
| 21 | Matt HarrisRBPark Hill (Kansas City) | 1411 | 108.5 | 7.31 | 193 | 84 | 13 | 2 | 13 |
| 22 | Justin DonaldRB, DBCrest Ridge (Centerview) | 1389 | 126.3 | 7.63 | 182 | 70 | 18 | 0 | 11 |
| 23 | Karsten EkernRB, MLBMexico | 1381 | 115.1 | 5.73 | 241 | 77 | 18 | 7 | 12 |
| 24 | Zayne KyserRB, OLBSalem | 1373 | 137.3 | 9.74 | 141 | 99 | 14 | 1 | 10 |
| 25 | Dalton WrightRB, DBWestran (Huntsville) | 1366 | 97.6 | 9.49 | 144 | 65 | 19 | 2 | 14 |
| 26 | Alex PyattRB, DBBLBHS (St. Joseph) | 1366 | 124.2 | 6.80 | 201 | 70 | 10 | 0 | 11 |
| 27 | Landon HarperRB, LBHerculaneum | 1314 | 146.0 | 5.48 | 240 | 74 | 9 | 0 | 9 |
| 28 | Richard RichardsonRB, FSLiberty North (Liberty) | 1308 | 109.0 | 6.51 | 201 | 68 | 8 | 5 | 12 |
| 29 | Tucker GruberRB, LBParis | 1304 | 118.5 | 7.49 | 174 | 61 | 23 | 5 | 11 |
| 30 | Steve WebbRB, MLBWCHS (St. Louis) | 1292 | 117.5 | 5.87 | 220 | 78 | 14 | 1 | 11 |
| 31 | Andy SatullaRB, OLBRolla | 1289 | 214.8 | 10.57 | 122 | 0 | 17 | 0 | 6 |
| 32 | Johnny HealyQB, SSMountain Grove | 1272 | 106.0 | 6.00 | 212 | 62 | 20 | 7 | 12 |
| 33 | Tyler DavisonRBWebb City | 1255 | 83.7 | 8.31 | 151 | 0 | 15 | 0 | 15 |
| 34 | JAKE ULMERRB, LBOsage (Kaiser) | 1245 | 95.8 | 6.80 | 183 | 92 | 10 | 5 | 13 |
| 35 | Robert RichmondRB, CBWillard | 1236 | 137.3 | 8.35 | 148 | 57 | 9 | 1 | 9 |
| 36 | Sutton SmithRB, SSHowell (St. Charles) | 1199 | 149.9 | 8.95 | 134 | 91 | 15 | 0 | 8 |
| 37 | Devin CottRB, SSMarshall | 1194 | 119.4 | 5.48 | 218 | 73 | 16 | 0 | 10 |
| 38 | Travis DeanRB, FSFulton | 1191 | 119.1 | 7.89 | 151 | 0 | 11 | 0 | 10 |
| 39 | Ben HinzQB, SSSanta Fe (Alma) | 1185 | 148.1 | 7.23 | 164 | 64 | 21 | 0 | 8 |
| 40 | Kolin ReynoldsRB, DBCrest Ridge (Centerview) | 1172 | 106.5 | 7.37 | 159 | 68 | 15 | 0 | 11 |
| 41 | Dallas ReynoldsQBWNHS (Wellington) | 1141 | 114.1 | 8.27 | 138 | 77 | 16 | 1 | 10 |
| 42 | Elza EvansRB, OLBLebanon | 1127 | 161.0 | 7.67 | 147 | 64 | 13 | 3 | 7 |
| 43 | Brett ThrelkeldQB, DBSouth Shelby (Shelbina) | 1106 | 85.1 | 5.85 | 189 | 67 | 20 | 2 | 13 |
| 44 | Dmilo NunnelleyRB, OLBMexico | 1104 | 92.0 | 11.26 | 98 | 97 | 11 | 5 | 12 |
| 45 | Alex DerryberryQB, FSCarthage | 1087 | 98.8 | 7.66 | 142 | 71 | 15 | 0 | 11 |
| 46 | Trystan SunbyRB, FSGallatin | 1084 | 120.4 | 6.23 | 174 | 55 | 16 | 4 | 9 |
| 47 | D'angelo PooleRB, SSCarthage | 1083 | 98.5 | 5.39 | 201 | 63 | 13 | 0 | 11 |
| 48 | Devon BryantRBLiberty | 1082 | 108.2 | 5.76 | 188 | 17 | 12 | 0 | 10 |
| 49 | Matt StumpRB, SSJasper | 1070 | 97.3 | 7.33 | 146 | 80 | 14 | 1 | 11 |
| 50 | Israel SmithRB, CBCentral (St. Joseph) | 1070 | 107.0 | 4.65 | 230 | 20 | 19 | 2 | 10 |