| 1 | Jay EdmundsonQB, SSPoplar Bluff | 2626 | 262.6 | 1950 | 676 | 0 | 10 |
| 2 | Keyshawn BoydRBCentral (Cape Girardeau) | 2150 | 165.4 | 8 | 2063 | 79 | 13 |
| 3 | Zai'aire ThomasRB, SBCentral (Cape Girardeau) | 1907 | 146.7 | 71 | 1338 | 498 | 13 |
| 4 | Brett DryeQB, CBFarmington | 1353 | 135.3 | 701 | 652 | 0 | 10 |
| 5 | Jathan SpainQB, LSCentral (Cape Girardeau) | 1138 | 87.5 | 1013 | 125 | 0 | 13 |
| 6 | Kaesen McclainRB, MLBFarmington | 1050 | 87.5 | 0 | 1026 | 24 | 12 |
| 7 | Romeoh WontorWR, DBPoplar Bluff | 856 | 85.6 | 0 | 0 | 856 | 10 |
| 8 | Darius GrahamFS, WRPoplar Bluff | 776 | 77.6 | 0 | 26 | 750 | 10 |
| 9 | Gabe GiulianiOLB, RBFarmington | 423 | 35.2 | 0 | 166 | 257 | 12 |
| 10 | Tatem TinsleyQB, FSFarmington | 401 | 33.4 | 160 | 241 | 0 | 12 |
| 11 | Connor RiceRB, FSFarmington | 366 | 30.5 | 0 | 195 | 171 | 12 |
| 12 | Paul TranCentral (Cape Girardeau) | 318 | 31.8 | 3 | 9 | 306 | 10 |
| 13 | Samuel WoodsonWRFarmington | 317 | 26.4 | 0 | 0 | 317 | 12 |
| 14 | Tae'Shawn ArnoldRBCentral (Cape Girardeau) | 299 | 37.4 | 0 | 287 | 12 | 8 |
| 15 | kolyn McbrideWR, RBPoplar Bluff | 227 | 25.2 | 0 | 227 | 0 | 9 |
| 16 | Logan HiteILB, HBPoplar Bluff | 207 | 20.7 | 0 | 195 | 12 | 10 |
| 17 | Hunter CliffordWR, SPoplar Bluff | 198 | 24.8 | 0 | 0 | 198 | 8 |
| 18 | Mason WestQB, WRPoplar Bluff | 176 | 29.3 | 145 | -6 | 37 | 6 |
| 19 | Carter ArmstrongWR, FSCentral (Cape Girardeau) | 172 | 28.7 | 0 | 0 | 172 | 6 |
| 20 | Dylan HallWR, CBPoplar Bluff | 147 | 14.7 | 0 | 0 | 147 | 10 |
| 21 | Parker BrooksWR, FSFarmington | 106 | 13.2 | 0 | 103 | 3 | 8 |
| 22 | Jais SotoCB, WRPoplar Bluff | 101 | 12.6 | 0 | 99 | 2 | 8 |
| 23 | Ian ZohnerWR, CBFarmington | 73 | 6.1 | 27 | 0 | 46 | 12 |
| 24 | Dereck BurtonPoplar Bluff | 72 | 14.4 | 0 | 0 | 72 | 5 |
| 25 | Avery PersonsOLB, RBPoplar Bluff | 69 | 7.7 | 0 | 69 | 0 | 9 |
| 26 | Raymond JacksonCentral (Cape Girardeau) | 66 | 13.2 | 0 | 56 | 10 | 5 |
| 27 | aiden prattDE, TEPoplar Bluff | 48 | 6.0 | 0 | 48 | 0 | 8 |
| 28 | Hunter HastingsWR, FSFarmington | 45 | 6.4 | 0 | 36 | 9 | 7 |
| 29 | Corde HightowerRB, SPoplar Bluff | 44 | 6.3 | 0 | 44 | 0 | 7 |
| 30 | Breijon ClemonsWR, RBCentral (Cape Girardeau) | 37 | 6.2 | 0 | 24 | 13 | 6 |
| 31 | Chase BuchananOLB, RBFarmington | 27 | 2.7 | 0 | 27 | 0 | 10 |
| 32 | Damian CabreraOLB, RBFarmington | 24 | 2.4 | 0 | -3 | 27 | 10 |
| 33 | Josh MccarthyRB, FSFarmington | 18 | 3.6 | 0 | 18 | 0 | 5 |
| 34 | Chapman OglesQB, DECentral (Cape Girardeau) | 18 | 4.5 | 19 | -1 | 0 | 4 |
| 35 | Neco GaddyTE, DEPoplar Bluff | 9 | 1.1 | 0 | 0 | 9 | 8 |
| 36 | Lincoln WarrenDE, TEPoplar Bluff | 7 | 0.7 | 0 | 0 | 7 | 10 |
| 37 | Caleb LeaskRB, SSFarmington | 7 | 0.9 | 0 | 7 | 0 | 8 |
| 38 | Rhett KauflinWR, CBFarmington | 6 | 0.9 | 0 | 0 | 6 | 7 |
| 39 | Jaylnn ChaversFSPoplar Bluff | 6 | 1.2 | 0 | 0 | 6 | 5 |
| 40 | Caden JenkinsILB, RBPoplar Bluff | 5 | 0.6 | 0 | 0 | 5 | 9 |
