| 1 | De'marion MewbornRB, OLBGates Chili (Rochester) | 1748 | 194.2 | 6.75 | 259 | 0 | 25 | 3 | 9 |
| 2 | Raykim ChenierRB, LBUP (Rochester) | 1511 | 137.4 | 7.95 | 190 | 92 | 12 | 1 | 11 |
| 3 | William Benjamin jrRB, CBAI (Rochester) | 1186 | 131.8 | 8.47 | 140 | 65 | 14 | 1 | 9 |
| 4 | Thomas WelchRB, SSAvon | 1170 | 106.4 | 6.06 | 193 | 0 | 13 | 0 | 11 |
| 5 | Eimaj GiddensRB, CBAI (Rochester) | 1068 | 97.1 | 8.75 | 122 | 63 | 8 | 1 | 11 |
| 6 | Andrew RowlandCB, QBAvon | 1004 | 91.3 | 6.31 | 159 | 0 | 16 | 0 | 11 |
| 7 | Brock FlintRB, OLBLe Roy | 766 | 76.6 | 4.88 | 157 | 46 | 8 | 6 | 10 |
| 8 | Sam GothamRB, FSVictor | 639 | 71.0 | 5.28 | 121 | 0 | 10 | 0 | 9 |
| 9 | Cj PalmiereTE, CBVictor | 597 | 74.6 | 4.89 | 122 | 0 | 3 | 1 | 8 |
| 10 | Xavier Jones RB, OLBGOGO (CO-OP) (Rochester) | 589 | 84.1 | 8.54 | 69 | 0 | 5 | 0 | 7 |
| 11 | Alex DerosaSSWSHS (Webster) | 499 | 55.4 | 5.87 | 85 | 40 | 3 | 0 | 9 |
| 12 | Kaleb JulianoWSHS (Webster) | 489 | 54.3 | 5.09 | 96 | 24 | 5 | 0 | 9 |
| 13 | Drew StrolloRB, LBLe Roy | 463 | 66.1 | 5.86 | 79 | 59 | 4 | 3 | 7 |
| 14 | Chris JeanRB, ATHUP (Rochester) | 367 | 36.7 | 9.18 | 40 | 55 | 2 | 0 | 10 |
| 15 | Devon MckoyCB, QBPalmyra-Macedon (Palmyra) | 359 | 51.3 | 4.66 | 77 | 30 | 3 | 5 | 7 |
| 16 | Neftali CruzFB, MLBGates Chili (Rochester) | 310 | 34.4 | 5.96 | 52 | 0 | 2 | 3 | 9 |
| 17 | Jakob DayOLB, TBPalmyra-Macedon (Palmyra) | 302 | 50.3 | 4.79 | 63 | 40 | 2 | 2 | 6 |
| 18 | Zymier JacksonQB, QBGOGO (CO-OP) (Rochester) | 248 | 35.4 | 6.70 | 37 | 0 | 1 | 2 | 7 |
| 19 | Tony PiazzaFB, OLBLe Roy | 247 | 27.4 | 8.23 | 30 | 28 | 4 | 1 | 9 |
| 20 | DeNiero Smith RB, DBGOGO (CO-OP) (Rochester) | 247 | 49.4 | 4.41 | 56 | 0 | 1 | 0 | 5 |
| 21 | Jahod FaisonWR, RBGOGO (CO-OP) (Rochester) | 210 | 30.0 | 17.50 | 12 | 0 | 1 | 0 | 7 |
| 22 | Eli AdamsQBWebster Thomas (Webster) | 186 | 62.0 | 6.41 | 29 | 27 | 4 | 2 | 3 |
| 23 | Adam RuffaloRB, CBVictor | 184 | 23.0 | 11.50 | 16 | 0 | 2 | 0 | 8 |
| 24 | Ivan Reynolds-diazDE, FBPalmyra-Macedon (Palmyra) | 172 | 24.6 | 3.13 | 55 | 17 | 1 | 0 | 7 |
| 25 | C.j. CammackRB, FSAI (Rochester) | 161 | 14.6 | 6.44 | 25 | 35 | 2 | 0 | 11 |
| 26 | Antonio MartinezWR, CBLe Roy | 122 | 12.2 | 2.77 | 44 | 14 | 7 | 5 | 10 |
| 27 | C.j. RobinsonRB, CBAI (Rochester) | 113 | 16.1 | 10.27 | 11 | 52 | 1 | 0 | 7 |
| 28 | Devin PearceRB, DLVictor | 110 | 22.0 | 5.79 | 19 | 0 | 1 | 0 | 5 |
| 29 | Jake DriscollRB, LBAvon | 101 | 14.4 | 5.94 | 17 | 0 | 1 | 0 | 7 |
| 30 | Dillon EnglishWebster Thomas (Webster) | 89 | 29.7 | 5.24 | 17 | 17 | 0 | 0 | 3 |
| 31 | Lavari SmithLB, RBUP (Rochester) | 87 | 17.4 | 10.88 | 8 | 29 | 1 | 0 | 5 |
| 32 | Emmanuel FisherRB, DELe Roy | 85 | 12.1 | 12.14 | 7 | 68 | 1 | 2 | 7 |
| 33 | Justin MaierWR, CBWSHS (Webster) | 80 | 11.4 | 4.00 | 20 | 19 | 1 | 1 | 7 |
| 34 | Amari Colon-BrownWR, SGOGO (CO-OP) (Rochester) | 77 | 12.8 | 15.40 | 5 | 0 | 1 | 0 | 6 |
| 35 | Marlon SalmonWR, OLBGates Chili (Rochester) | 75 | 9.4 | 5.00 | 15 | 0 | 0 | 0 | 8 |
| 36 | Nazir WynnDL, HBUP (Rochester) | 70 | 7.0 | 10.00 | 7 | 0 | 1 | 0 | 10 |
| 37 | Tyler StrolloFB, OLBLe Roy | 70 | 7.0 | 5.38 | 13 | 24 | 0 | 2 | 10 |
| 38 | Tabor SirianiWSHS (Webster) | 70 | 8.8 | 4.38 | 16 | 21 | 0 | 0 | 8 |
| 39 | Richie BriceQB, LBAvon | 69 | 6.3 | 4.93 | 14 | 0 | 0 | 0 | 11 |
| 40 | Chris ThompsonWR, CBAvon | 59 | 5.4 | 5.90 | 10 | 0 | 1 | 0 | 11 |
| 41 | Bryce ConyersRB, LBAI (Rochester) | 59 | 7.4 | 4.92 | 12 | 12 | 0 | 0 | 8 |
| 42 | Todd GilliamWR, DBUP (Rochester) | 56 | 5.1 | 7.00 | 8 | 11 | 1 | 0 | 11 |
| 43 | Terreque DavisRB, CBVictor | 56 | 14.0 | 5.09 | 11 | 0 | 1 | 0 | 4 |
| 44 | Marley EnglishWebster Thomas (Webster) | 52 | 17.3 | 4.73 | 11 | 15 | 1 | 1 | 3 |
| 45 | Jacob SukhenkoWebster Thomas (Webster) | 51 | 17.0 | 3.40 | 15 | 11 | 2 | 0 | 3 |
| 46 | Clyde Davis Jr.QBUP (Rochester) | 49 | 4.5 | 7.00 | 7 | 22 | 0 | 0 | 11 |
| 47 | Terreque DavisRB, CBVictor | 48 | 9.6 | 2.67 | 18 | 0 | 0 | 0 | 5 |
| 48 | Mark McClaryWR, DBUP (Rochester) | 40 | 4.0 | 20.00 | 2 | 0 | 1 | 0 | 10 |
| 49 | Anthony DerosaRB, OLBWSHS (Webster) | 37 | 9.2 | 3.70 | 10 | 11 | 0 | 1 | 4 |
| 50 | Matt BradyQB, FSVictor | 37 | 4.1 | 1.00 | 37 | 0 | 2 | 0 | 9 |
