| 1 | Tyler RouseRB, OLBBaldwinsville | 2977 | 297.7 | 8.94 | 333 | 75 | 45 | 0 | 10 |
| 2 | Colby TrexlerRB, DBJordan-Elbridge (Jordan) | 1349 | 168.6 | 7.10 | 190 | 64 | 12 | 0 | 8 |
| 3 | Max WeissRB, DBSkaneateles | 1293 | 117.5 | 6.53 | 198 | 0 | 10 | 1 | 11 |
| 4 | Mike SpainRB, DLTully | 1103 | 137.9 | 8.62 | 128 | 66 | 10 | 1 | 8 |
| 5 | Corey WilkinsonRB, DEBishop Ludden (Syracuse) | 1089 | 121.0 | 7.51 | 145 | 71 | 12 | 2 | 9 |
| 6 | Brandon BurnettRB, DBHannibal | 1013 | 126.6 | 6.58 | 154 | 72 | 8 | 1 | 8 |
| 7 | Zack GreenQB, DBWestmoreland | 991 | 110.1 | 6.65 | 149 | 65 | 17 | 14 | 9 |
| 8 | Robert HeitzmannRB, LBWestmoreland | 789 | 78.9 | 5.60 | 141 | 28 | 3 | 2 | 10 |
| 9 | Tim HarrisonRB, DBWestmoreland | 773 | 77.3 | 6.78 | 114 | 35 | 13 | 3 | 10 |
| 10 | Mark DoveRB, LBHomer | 760 | 95.0 | 5.67 | 134 | 85 | 6 | 0 | 8 |
| 11 | Javon EvansRB, DBProctor (Utica) | 724 | 90.5 | 7.62 | 95 | 61 | 7 | 0 | 8 |
| 12 | Connor O'NeilRB, DESVHS (Sauquoit) | 653 | 81.6 | 5.78 | 113 | 0 | 7 | 0 | 8 |
| 13 | Lawrence ElliottRB, LBProctor (Utica) | 589 | 73.6 | 7.10 | 83 | 62 | 7 | 1 | 8 |
| 14 | Conor HerrLB, QBSkaneateles | 589 | 53.5 | 5.78 | 102 | 64 | 6 | 3 | 11 |
| 15 | David PooleFB, MLBLFFP (CO-OP) (LaFayette) | 513 | 102.6 | 5.83 | 88 | 0 | 4 | 6 | 5 |
| 16 | Alec VoceLB, RBSVHS (Sauquoit) | 512 | 64.0 | 5.28 | 97 | 0 | 4 | 0 | 8 |
| 17 | Billy SteinmetzHB, FSLFFP (CO-OP) (LaFayette) | 487 | 60.9 | 6.58 | 74 | 0 | 3 | 7 | 8 |
| 18 | Nate DoodyQB, LBTully | 454 | 56.8 | 6.31 | 72 | 43 | 3 | 6 | 8 |
| 19 | Zack HardingWR, DBBishop Ludden (Syracuse) | 423 | 47.0 | 6.93 | 61 | 86 | 3 | 2 | 9 |
| 20 | Ricky SparksRB, DBBaldwinsville | 411 | 41.1 | 8.39 | 49 | 88 | 5 | 0 | 10 |
| 21 | Spencer SharlowRB, LBIHCHS (Watertown) | 378 | 47.2 | 6.10 | 62 | 33 | 9 | 0 | 8 |
| 22 | Lucas LyonsRB, DBCooperstown | 372 | 46.5 | 5.24 | 71 | 0 | 3 | 0 | 8 |
| 23 | Michael MarraRB, DBIHCHS (Watertown) | 358 | 44.8 | 5.34 | 67 | 43 | 7 | 3 | 8 |
| 24 | Brett McKinneyFB, OLBRome Free Academy (Rome) | 334 | 41.8 | 5.86 | 57 | 23 | 3 | 4 | 8 |
| 25 | Adam VanWartRB, DBJordan-Elbridge (Jordan) | 333 | 41.6 | 4.76 | 70 | 33 | 1 | 0 | 8 |
| 26 | Anthony PecorielloFB, LBBishop Ludden (Syracuse) | 332 | 47.4 | 13.83 | 24 | 54 | 2 | 0 | 7 |
| 27 | Jimmy DurkeeRB, DBHomer | 290 | 41.4 | 7.25 | 40 | 70 | 3 | 1 | 7 |
| 28 | Eddie CamposWR, DBRome Free Academy (Rome) | 267 | 33.4 | 4.17 | 64 | 80 | 2 | 5 | 8 |
| 29 | Timothy WebberQB, DBHannibal | 260 | 32.5 | 5.78 | 45 | 50 | 4 | 0 | 8 |
| 30 | Austin FrechetteRB, LBIHCHS (Watertown) | 245 | 35.0 | 5.83 | 42 | 35 | 2 | 1 | 7 |
| 31 | Jayden GavidiaRB, DBHomer | 229 | 28.6 | 6.19 | 37 | 51 | 4 | 2 | 8 |
| 32 | Brandon MaxsonRB, DLHomer | 195 | 24.4 | 5.74 | 34 | 23 | 2 | 1 | 8 |
| 33 | Brad McmahonRB, DBJordan-Elbridge (Jordan) | 193 | 24.1 | 3.78 | 51 | 17 | 3 | 0 | 8 |
| 34 | EJ PerezHB, ILBCooperstown | 182 | 26.0 | 3.96 | 46 | 0 | 1 | 1 | 7 |
| 35 | Julius BerryTB, DBRome Free Academy (Rome) | 165 | 23.6 | 5.32 | 31 | 18 | 2 | 2 | 7 |
| 36 | Syrrus NashWR, DBTully | 157 | 19.6 | 13.08 | 12 | 75 | 1 | 0 | 8 |
| 37 | Antoine MontgomeryWR, DBBishop Ludden (Syracuse) | 153 | 17.0 | 10.93 | 14 | 24 | 0 | 0 | 9 |
| 38 | Cole BurchillFB, MLBBaldwinsville | 147 | 14.7 | 9.80 | 15 | 63 | 1 | 0 | 10 |
| 39 | Devin WilliamsRB, LBWestmoreland | 141 | 23.5 | 5.88 | 24 | 45 | 2 | 2 | 6 |
| 40 | Haden BakerQB, DBIHCHS (Watertown) | 140 | 17.5 | 5.00 | 28 | 31 | 0 | 1 | 8 |
| 41 | Greg HadcockRB, DBHannibal | 139 | 17.4 | 4.79 | 29 | 40 | 0 | 0 | 8 |
| 42 | Chris MuellerHB, CLFFP (CO-OP) (LaFayette) | 132 | 16.5 | 5.08 | 26 | 0 | 1 | 1 | 8 |
| 43 | Jake HayesWR, DBHomer | 131 | 26.2 | 13.10 | 10 | 56 | 2 | 1 | 5 |
| 44 | Josiah LongRB, DLTully | 131 | 18.7 | 10.92 | 12 | 35 | 2 | 0 | 7 |
| 45 | Jordan TreenQB, DBProctor (Utica) | 131 | 16.4 | 4.37 | 30 | 18 | 0 | 1 | 8 |
| 46 | Nico CheriTB, DBRome Free Academy (Rome) | 128 | 21.3 | 6.74 | 19 | 21 | 1 | 0 | 6 |
| 47 | Jake CaseyRB, DBHomer | 125 | 15.6 | 5.95 | 21 | 30 | 3 | 0 | 8 |
| 48 | Elliott MuellerHB, MLBLFFP (CO-OP) (LaFayette) | 123 | 30.8 | 3.97 | 31 | 0 | 0 | 4 | 4 |
| 49 | Joey BeckerFB, LBWestmoreland | 121 | 30.2 | 6.72 | 18 | 13 | 2 | 0 | 4 |
| 50 | Chris SimmonsWR, DLProctor (Utica) | 119 | 14.9 | 8.50 | 14 | 34 | 0 | 1 | 8 |