| 1 | Brian KingsboroughRB, DLClinton | 2009 | 167.4 | 8.48 | 237 | 85 | 28 | 0 | 12 |
| 2 | Gabe GilmourQB, FSHHCA (Hilton Head Island) | 1695 | 130.4 | 7.18 | 236 | 65 | 26 | 0 | 13 |
| 3 | Richard MounceBlythewood | 1108 | 73.9 | 5.92 | 187 | 68 | 9 | 11 | 15 |
| 4 | Ikaika KapuFB, LBSt. Andrew's (Savannah) | 1000 | 125.0 | 5.75 | 174 | 0 | 8 | 0 | 8 |
| 5 | Eric CurryRBStrom Thurmond (Johnston) | 999 | 83.2 | 5.02 | 199 | 0 | 0 | 0 | 12 |
| 6 | Quinton SingletonRB, DBSBHS (Summerton) | 925 | 84.1 | 5.11 | 181 | 88 | 3 | 0 | 11 |
| 7 | Deonte GistRB, WRJames F. Byrnes (Duncan) | 839 | 64.5 | 7.56 | 111 | 63 | 6 | 0 | 13 |
| 8 | Quincy PalmerRB, DBSBHS (Summerton) | 763 | 84.8 | 6.69 | 114 | 82 | 8 | 0 | 9 |
| 9 | Aramis HillaryQBStrom Thurmond (Johnston) | 752 | 62.7 | 4.82 | 156 | 0 | 0 | 0 | 12 |
| 10 | Blake FergusonRB, LBCA (North Charleston) | 621 | 62.1 | 7.31 | 85 | 23 | 0 | 0 | 10 |
| 11 | Tim PalmerRB, DBSBHS (Summerton) | 544 | 49.5 | 5.61 | 97 | 44 | 2 | 0 | 11 |
| 12 | Rodney JamisonBlythewood | 497 | 35.5 | 4.52 | 110 | 34 | 10 | 4 | 14 |
| 13 | Thomas GreenWB, FSSt. Andrew's (Savannah) | 472 | 47.2 | 7.38 | 64 | 0 | 4 | 0 | 10 |
| 14 | Jeremiah CochranRBGaffney | 449 | 44.9 | 4.93 | 91 | 0 | 11 | 0 | 10 |
| 15 | Willy KornQBJames F. Byrnes (Duncan) | 433 | 33.3 | 2.91 | 149 | 46 | 14 | 0 | 13 |
| 16 | Matthew CarrabbaRB, LBHHCA (Hilton Head Island) | 426 | 35.5 | 6.87 | 62 | 32 | 5 | 0 | 12 |
| 17 | Steffen FosterRBGaffney | 421 | 42.1 | 4.38 | 96 | 0 | 7 | 0 | 10 |
| 18 | Jones BrownQB, DBCNHS (Columbia) | 401 | 50.1 | 3.64 | 110 | 74 | 1 | 0 | 8 |
| 19 | Jon HopeHB, CBSt. Andrew's (Savannah) | 393 | 39.3 | 5.17 | 76 | 0 | 3 | 0 | 10 |
| 20 | George HiltonOL, DLSBHS (Summerton) | 386 | 35.1 | 4.76 | 81 | 33 | 4 | 0 | 11 |
| 21 | Arsi RobersonRB, DBClinton | 348 | 38.7 | 6.10 | 57 | 33 | 7 | 0 | 9 |
| 22 | James WilkersonBlythewood | 339 | 26.1 | 5.06 | 67 | 34 | 8 | 3 | 13 |
| 23 | Marcus LattimoreRB, FBJames F. Byrnes (Duncan) | 338 | 30.7 | 5.20 | 65 | 40 | 6 | 0 | 11 |
| 24 | Billy CrouseRB, DEClinton | 314 | 26.2 | 5.71 | 55 | 27 | 3 | 0 | 12 |
| 25 | Anthony TyusRBGaffney | 312 | 31.2 | 5.47 | 57 | 0 | 4 | 0 | 10 |
| 26 | Kelton HallRB, LBClinton | 300 | 25.0 | 4.92 | 61 | 37 | 2 | 0 | 12 |
| 27 | Nick BoulayLB, FBHHCA (Hilton Head Island) | 247 | 19.0 | 5.15 | 48 | 33 | 6 | 0 | 13 |
| 28 | Freddie ByrdRB, DBClinton | 243 | 20.2 | 4.12 | 59 | 16 | 4 | 0 | 12 |
| 29 | Thomas WinsteadWR, DBCNHS (Columbia) | 241 | 34.4 | 5.74 | 42 | 80 | 1 | 0 | 7 |
| 30 | Palmer StokesQB, DBCNHS (Columbia) | 210 | 35.0 | 2.92 | 72 | 19 | 3 | 0 | 6 |
| 31 | Malcolm LongQBGaffney | 202 | 20.2 | 3.54 | 57 | 0 | 2 | 0 | 10 |
| 32 | Dontavius GlennQB, DBClinton | 197 | 16.4 | 3.28 | 60 | 26 | 2 | 0 | 12 |
| 33 | Will GarnettRB, LBCNHS (Columbia) | 196 | 21.8 | 5.16 | 38 | 51 | 4 | 0 | 9 |
| 34 | Perry WilsonBlythewood | 169 | 11.3 | 5.83 | 29 | 28 | 1 | 3 | 15 |
| 35 | Byron DoanQB, DBCA (North Charleston) | 168 | 16.8 | 5.79 | 29 | 13 | 0 | 0 | 10 |
| 36 | Trobias BrownRB, DLClinton | 137 | 17.1 | 5.71 | 24 | 34 | 1 | 0 | 8 |
| 37 | Curtis DavisRB, DBSBHS (Summerton) | 135 | 15.0 | 4.22 | 32 | 17 | 0 | 0 | 9 |
| 38 | Keith PoughQB, DBSBHS (Summerton) | 133 | 16.6 | 3.91 | 34 | 14 | 2 | 0 | 8 |
| 39 | Jakar HamiltonRB, WRStrom Thurmond (Johnston) | 131 | 10.9 | 4.09 | 32 | 0 | 0 | 0 | 12 |
| 40 | James WilliamsRB, LBCNHS (Columbia) | 119 | 17.0 | 6.26 | 19 | 34 | 2 | 0 | 7 |
| 41 | Eddie JefferiesOLBGaffney | 109 | 10.9 | 4.04 | 27 | 0 | 0 | 0 | 10 |
| 42 | David CampbellDB, WRStrom Thurmond (Johnston) | 103 | 8.6 | 6.87 | 15 | 0 | 0 | 0 | 12 |
| 43 | Greg AndersonG, DTCA (North Charleston) | 87 | 8.7 | 2.07 | 42 | 6 | 0 | 0 | 10 |
| 44 | Tyris SimpsonRB, DBClinton | 81 | 11.6 | 2.79 | 29 | 10 | 1 | 0 | 7 |
| 45 | William CubbageWR, DBHHCA (Hilton Head Island) | 77 | 5.9 | 5.13 | 15 | 12 | 1 | 0 | 13 |
| 46 | Jamel WatsonRBJames F. Byrnes (Duncan) | 73 | 8.1 | 4.06 | 18 | 20 | 1 | 0 | 9 |
| 47 | Joey DavisDB, TEHHCA (Hilton Head Island) | 63 | 5.2 | 5.73 | 11 | 32 | 1 | 0 | 12 |
| 48 | Taylor CookQB, DBClinton | 63 | 7.9 | 3.94 | 16 | 26 | 0 | 0 | 8 |
| 49 | Brandon HallWR, DBCNHS (Columbia) | 62 | 7.8 | 1.88 | 33 | 9 | 0 | 0 | 8 |
| 50 | Javon BrownWRStrom Thurmond (Johnston) | 58 | 4.8 | 4.83 | 12 | 0 | 0 | 0 | 12 |