| 1 | Chris RobinsonSeneca | 2237 | 203.4 | 10.81 | 207 | 0 | 19 | 0 | 11 |
| 2 | Rondreas TruesdaleQB, DBIndian Land (Fort Mill) | 2120 | 192.7 | 9.95 | 213 | 81 | 34 | 0 | 11 |
| 3 | Kevin MillerRBLexington | 1693 | 169.3 | 8.38 | 202 | 71 | 24 | 1 | 10 |
| 4 | Gregg JohnsenRB, LBSJHS (Murrells Inlet) | 1586 | 158.6 | 6.81 | 233 | 97 | 14 | 0 | 10 |
| 5 | Tyler RenewRB, LBBen Lippen (Columbia) | 1518 | 168.7 | 9.14 | 166 | 84 | 19 | 0 | 9 |
| 6 | Caleb KinlawRBGoose Creek | 1497 | 99.8 | 8.51 | 176 | 64 | 8 | 0 | 15 |
| 7 | Carlos HicksonQB, DBECHS (Turbeville) | 1407 | 140.7 | 8.85 | 159 | 50 | 14 | 1 | 10 |
| 8 | Darius PaulkRBRNHS (Columbia) | 1374 | 124.9 | 6.30 | 218 | 60 | 11 | 0 | 11 |
| 9 | Devontae ShepherdRB, SCross | 1319 | 109.9 | 7.90 | 167 | 82 | 19 | 1 | 12 |
| 10 | Keynnard CampbellRB, QBBible Baptist (Savannah) | 1307 | 145.2 | 6.99 | 187 | 62 | 8 | 2 | 9 |
| 11 | Thomas BanksRBACHS (Martinez) | 1283 | 116.6 | 6.75 | 190 | 0 | 17 | 0 | 11 |
| 12 | Virgil SmallsFBGoose Creek | 1279 | 85.3 | 5.26 | 243 | 44 | 40 | 0 | 15 |
| 13 | Leon MathisRB, DBSBHS (Summerton) | 1267 | 158.4 | 5.44 | 233 | 55 | 16 | 0 | 8 |
| 14 | Davidmichael ClarkRBKeenan (Columbia) | 1254 | 104.5 | 6.21 | 202 | 54 | 9 | 0 | 12 |
| 15 | Shakeem WhartonRBJames F. Byrnes (Duncan) | 1250 | 96.2 | 5.27 | 237 | 73 | 18 | 2 | 13 |
| 16 | Daniel JacksonRBNation Ford (Fort Mill) | 1199 | 99.9 | 5.38 | 223 | 0 | 12 | 0 | 12 |
| 17 | LaMichael PushiaRB, DBHemingway | 1170 | 146.2 | 9.67 | 121 | 0 | 18 | 0 | 8 |
| 18 | Ky TylerQB, DEColumbia | 1157 | 96.4 | 5.87 | 197 | 45 | 20 | 6 | 12 |
| 19 | Devin HollandWB, ILBMid-Carolina (Prosperity) | 1154 | 104.9 | 6.52 | 177 | 0 | 15 | 0 | 11 |
| 20 | Anthony EnosRBCane Bay (Summerville) | 1116 | 139.5 | 6.41 | 174 | 52 | 10 | 0 | 8 |
| 21 | Devin PearsonQB, DBSouth Pointe (Rock Hill) | 1100 | 73.3 | 5.29 | 208 | 70 | 14 | 11 | 15 |
| 22 | C.j MillerRBGaffney | 1089 | 72.6 | 5.09 | 214 | 39 | 13 | 4 | 15 |
| 23 | Darin WashingtonFB, LBDenmark-Olar (Denmark) | 1079 | 107.9 | 8.50 | 127 | 85 | 7 | 0 | 10 |
| 24 | Jaquan MarshQBGoose Creek | 1062 | 70.8 | 7.53 | 141 | 66 | 12 | 0 | 15 |
| 25 | Nick Sims-mettsWB, DBMid-Carolina (Prosperity) | 1045 | 104.5 | 7.46 | 140 | 0 | 18 | 0 | 10 |
| 26 | Trey EavesRB, DBIndian Land (Fort Mill) | 1030 | 93.6 | 8.66 | 119 | 71 | 11 | 1 | 11 |
| 27 | Latreal TorrenceRBStall (Charleston) | 1006 | 100.6 | 6.99 | 144 | 62 | 0 | 0 | 10 |
| 28 | Ryan MooreRB, LBClover | 1005 | 91.4 | 4.41 | 228 | 99 | 11 | 11 | 11 |
| 29 | Daniel DrakefordRB, DBWilson Hall (Sumter) | 1001 | 77.0 | 8.34 | 120 | 57 | 13 | 0 | 13 |
| 30 | James LoweryCB, RBWilson Hall (Sumter) | 969 | 74.5 | 7.51 | 129 | 46 | 7 | 0 | 13 |
| 31 | Lavadrick GlennClinton | 946 | 94.6 | 5.60 | 169 | 58 | 12 | 0 | 10 |
| 32 | Jared LayneRB, DBSCHS (Simpsonville) | 945 | 85.9 | 7.27 | 130 | 70 | 15 | 0 | 11 |
| 33 | Stuart WaltersAMHS (North Charleston) | 939 | 156.5 | 14.23 | 66 | 70 | 14 | 0 | 6 |
| 34 | Tyler ChisholmRB, DBHHCA (Hilton Head Island) | 926 | 77.2 | 6.81 | 136 | 65 | 9 | 0 | 12 |
| 35 | Rayshad BennettRBSumter | 926 | 77.2 | 6.09 | 152 | 80 | 7 | 3 | 12 |
| 36 | Daetron HymanRBKeenan (Columbia) | 897 | 74.8 | 5.22 | 172 | 40 | 4 | 0 | 12 |
| 37 | Leonard LeakRBGeorgetown | 881 | 88.1 | 5.28 | 167 | 51 | 9 | 2 | 10 |
| 38 | Tyshawn RichardsonRB, OLBBlue Ridge (Greer) | 878 | 79.8 | 7.08 | 124 | 80 | 15 | 0 | 11 |
| 39 | Trae EarleSeneca | 855 | 77.7 | 7.50 | 114 | 0 | 6 | 0 | 11 |
| 40 | Aaron CrandallRB, DBOP (Orangeburg) | 852 | 77.5 | 5.92 | 144 | 0 | 5 | 0 | 11 |
| 41 | Davenick TisdaleQB, RBCEMHS (Greeleyville) | 852 | 94.7 | 4.66 | 183 | 24 | 8 | 0 | 9 |
| 42 | Tramel TerryWR, RBGoose Creek | 847 | 56.5 | 7.24 | 117 | 59 | 10 | 0 | 15 |
| 43 | Teron DaleyRB, DBHHP (Hilton Head Island) | 842 | 84.2 | 7.80 | 108 | 77 | 8 | 4 | 10 |
| 44 | NaJahwan McKinstryQB, DBFCHS (Winnsboro) | 825 | 91.7 | 6.25 | 132 | 55 | 10 | 0 | 9 |
| 45 | Levi BuffordRBWren (Piedmont) | 822 | 91.3 | 6.47 | 127 | 71 | 13 | 3 | 9 |
| 46 | Shaq BacoteQB, DBByrnes (Florence) | 806 | 62.0 | 6.35 | 127 | 66 | 12 | 5 | 13 |
| 47 | Jalen FrazierQB, DBCross | 791 | 65.9 | 6.76 | 117 | 63 | 7 | 8 | 12 |
| 48 | Brandon CannonQBLandrum | 785 | 65.4 | 5.06 | 155 | 0 | 12 | 0 | 12 |
| 49 | Earnest TalfordRB, MLBGreat Falls | 775 | 77.5 | 7.60 | 102 | 60 | 0 | 0 | 10 |
| 50 | Anthony HenleyClinton | 774 | 86.0 | 5.13 | 151 | 55 | 8 | 0 | 9 |
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