| 1 | Chris RobertsRB, OLBSouth Aiken (Aiken) | 2020 | 134.7 | 6.89 | 293 | 24 | 26 | 0 | 15 |
| 2 | Ryan SmithRB, LBACHS (Anderson) | 1854 | 154.5 | 7.60 | 244 | 48 | 21 | 1 | 12 |
| 3 | Ronald (rj) RoderickQB, RBCane Bay (Summerville) | 1778 | 148.2 | 7.76 | 229 | 78 | 23 | 3 | 12 |
| 4 | Ron HoffRBDutch Fork (Irmo) | 1762 | 117.5 | 7.50 | 235 | 60 | 28 | 2 | 15 |
| 5 | Richard GarvinRB, CBAFHS (Fairfax) | 1695 | 154.1 | 8.23 | 206 | 62 | 19 | 7 | 11 |
| 6 | Irvin MulliganLB, RBWhale Branch (Beaufort) | 1678 | 139.8 | 7.42 | 226 | 0 | 25 | 1 | 12 |
| 7 | Makiah SimmonsRB, LBBBHS (Orangeburg) | 1528 | 138.9 | 7.64 | 200 | 66 | 15 | 0 | 11 |
| 8 | Larrynz GivensRB, WRSJHS (John's Island) | 1414 | 141.4 | 7.90 | 179 | 42 | 0 | 0 | 10 |
| 9 | Monte PrattCheraw | 1399 | 107.6 | 10.93 | 128 | 61 | 11 | 0 | 13 |
| 10 | Oryan WarrenRBBHPHS (Honea Path) | 1368 | 114.0 | 6.77 | 202 | 86 | 16 | 1 | 12 |
| 11 | Tyrece NickQB, WRStrom Thurmond (Johnston) | 1258 | 104.8 | 6.62 | 190 | 56 | 13 | 7 | 12 |
| 12 | Nathan WalkerMLB, FBCross | 1256 | 114.2 | 11.12 | 113 | 65 | 14 | 1 | 11 |
| 13 | Mykal LeeRB, OLBBarnwell | 1249 | 89.2 | 7.52 | 166 | 80 | 13 | 0 | 14 |
| 14 | Damon DefordRB, FBCane Bay (Summerville) | 1245 | 103.8 | 6.62 | 188 | 45 | 12 | 2 | 12 |
| 15 | Mahammud GrahamRB, MLBGSFHS (Green Sea) | 1188 | 99.0 | 5.53 | 215 | 0 | 14 | 2 | 12 |
| 16 | Ali KelleyRBRidge View (Columbia) | 1185 | 107.7 | 8.01 | 148 | 80 | 15 | 0 | 11 |
| 17 | Tony RuffRBFCHS (Winnsboro) | 1178 | 107.1 | 10.52 | 112 | 0 | 9 | 1 | 11 |
| 18 | D.j. TwittyRB, MLBChapman (Inman) | 1176 | 147.0 | 5.57 | 211 | 49 | 12 | 0 | 8 |
| 19 | Rodney PittsRBSumter | 1174 | 106.7 | 6.18 | 190 | 66 | 23 | 8 | 11 |
| 20 | Diaz AlexanderRB, DBDillon Christian (Dillon) | 1166 | 97.2 | 8.57 | 136 | 62 | 18 | 1 | 12 |
| 21 | Anton BuxtonRBBarnwell | 1165 | 83.2 | 6.26 | 186 | 58 | 15 | 0 | 14 |
| 22 | Malik WilliamsQB, DBChester | 1146 | 127.3 | 7.90 | 145 | 0 | 19 | 0 | 9 |
| 23 | Dylven CovingtonRB, WRMCHS (Bennettsville) | 1142 | 142.8 | 7.46 | 153 | 81 | 6 | 6 | 8 |
| 24 | K.j. RodgersRB, WRBSHS (Spartanburg) | 1137 | 75.8 | 5.24 | 217 | 54 | 16 | 1 | 15 |
| 25 | Zachariah DoeRB, FSHHCA (Hilton Head Island) | 1111 | 138.9 | 6.28 | 177 | 71 | 9 | 1 | 8 |
| 26 | Rod EdmondsRBFCHS (Winnsboro) | 1107 | 85.2 | 8.39 | 132 | 0 | 14 | 2 | 13 |
| 27 | Michael MingesQB, WRDillon Christian (Dillon) | 1105 | 85.0 | 10.14 | 109 | 73 | 15 | 1 | 13 |
| 28 | Reese NicholsQBDutch Fork (Irmo) | 1085 | 72.3 | 7.04 | 154 | 61 | 16 | 4 | 15 |
| 29 | Devin VoRB, CBWhitmire | 1079 | 98.1 | 5.07 | 213 | 70 | 11 | 3 | 11 |
| 30 | Jerry HowardRBNorthwestern (Rock Hill) | 1053 | 95.7 | 6.88 | 153 | 71 | 15 | 1 | 11 |
| 31 | Jay UrichQBWren (Piedmont) | 1036 | 94.2 | 5.66 | 183 | 0 | 15 | 3 | 11 |
| 32 | Kris CopelandSB, RBCane Bay (Summerville) | 1002 | 83.5 | 8.87 | 113 | 50 | 14 | 1 | 12 |
| 33 | Cedrick CunninghamRB, SSNorth Central (Kershaw) | 963 | 137.6 | 7.83 | 123 | 67 | 11 | 3 | 7 |
| 34 | Steven SchlosserAMHS (North Charleston) | 952 | 86.5 | 5.12 | 186 | 55 | 11 | 3 | 11 |
| 35 | Latheron Rogers-andersonRB, FSRidge View (Columbia) | 945 | 72.7 | 9.54 | 99 | 61 | 11 | 0 | 13 |
| 36 | Trey GrayRB, DBWren (Piedmont) | 942 | 94.2 | 5.32 | 177 | 0 | 10 | 9 | 10 |
| 37 | Isaiah MorrisRB, FSChesnee | 941 | 94.1 | 8.56 | 110 | 0 | 15 | 0 | 10 |
| 38 | D'marco JacksonOLB, SSBroome (Spartanburg) | 935 | 155.8 | 8.50 | 110 | 80 | 7 | 3 | 6 |
| 39 | Deshawn WilliamsSS, RBSouth Florence (Florence) | 928 | 92.8 | 5.69 | 163 | 56 | 9 | 0 | 10 |
| 40 | Cameron RiceMLB, RBGaffney | 918 | 76.5 | 4.91 | 187 | 51 | 15 | 2 | 12 |
| 41 | Tony McfaddenRBSouth Florence (Florence) | 914 | 91.4 | 8.54 | 107 | 75 | 9 | 0 | 10 |
| 42 | Fisher JacksonQB, SSCPA (Walterboro) | 902 | 90.2 | 7.58 | 119 | 74 | 11 | 4 | 10 |
| 43 | Paul JohnsonRB, FSWestside (Anderson) | 897 | 81.5 | 4.90 | 183 | 0 | 12 | 2 | 11 |
| 44 | Jacob ReevesRBDA (St. George) | 888 | 126.9 | 6.21 | 143 | 82 | 9 | 1 | 7 |
| 45 | Nick PadgettWR, CBCPA (Walterboro) | 879 | 87.9 | 12.04 | 73 | 65 | 13 | 1 | 10 |
| 46 | Ontario McclellanRB, CBLatta | 871 | 72.6 | 7.85 | 111 | 65 | 11 | 0 | 12 |
| 47 | Brantley HudsonTE, OLBCPA (Walterboro) | 863 | 86.3 | 7.19 | 120 | 51 | 9 | 3 | 10 |
| 48 | Rashad BattisteRB, OLBJohn Paul II (Ridgeland) | 862 | 107.8 | 7.07 | 122 | 0 | 12 | 0 | 8 |
| 49 | Justin TimmonsRB, LBWilson Hall (Sumter) | 833 | 83.3 | 5.41 | 154 | 91 | 9 | 0 | 10 |
| 50 | Tavarius EllisRB, CBCCHS (St. Matthews) | 826 | 75.1 | 6.40 | 129 | 54 | 7 | 0 | 11 |
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