| 1 | Zach DoeRB, ATHJohn Paul II (Ridgeland) | 1918 | 174.4 | 8.20 | 234 | 82 | 25 | 1 | 11 |
| 2 | Ailym FordRB, MLBWest Florence (Florence) | 1836 | 153.0 | 7.20 | 255 | 92 | 17 | 2 | 12 |
| 3 | Diaz AlexanderQB, DBDillon Christian (Dillon) | 1752 | 134.8 | 10.13 | 173 | 81 | 26 | 2 | 13 |
| 4 | Jaquan EdwardsRB, MLBStrom Thurmond (Johnston) | 1741 | 158.3 | 7.08 | 246 | 50 | 19 | 4 | 11 |
| 5 | Jr PattersonRB, CBTHA (Ridgeland) | 1700 | 154.5 | 13.18 | 129 | 53 | 15 | 0 | 11 |
| 6 | Quan PittmanRBCheraw | 1595 | 122.7 | 5.86 | 272 | 0 | 17 | 0 | 13 |
| 7 | Chris RobertsRBSouth Aiken (Aiken) | 1584 | 132.0 | 6.31 | 251 | 34 | 18 | 1 | 12 |
| 8 | Jack AlvarezRB, SSGCHS (Greenwood) | 1528 | 169.8 | 8.08 | 189 | 70 | 20 | 0 | 9 |
| 9 | Demontez AlfordDE, RBDillon Christian (Dillon) | 1510 | 116.2 | 9.93 | 152 | 62 | 18 | 5 | 13 |
| 10 | Danyaus Williams-byrdMLB, RBGreenville | 1489 | 114.5 | 6.31 | 236 | 39 | 21 | 2 | 13 |
| 11 | Kris CopelandSB, RBCane Bay (Summerville) | 1487 | 123.9 | 9.85 | 151 | 74 | 19 | 5 | 12 |
| 12 | Michel DukesRBFBS (Charleston) | 1465 | 146.5 | 10.03 | 146 | 70 | 27 | 1 | 10 |
| 13 | D.j. TwittyRB, MLBChapman (Inman) | 1457 | 145.7 | 7.71 | 189 | 54 | 21 | 0 | 10 |
| 14 | Thomas MorganRB, MLBDorman (Roebuck) | 1456 | 97.1 | 8.42 | 173 | 62 | 15 | 4 | 15 |
| 15 | Nathan WalkerMLB, FBCross | 1417 | 141.7 | 10.42 | 136 | 77 | 17 | 1 | 10 |
| 16 | Irvin MulliganMLB, RBWhale Branch (Beaufort) | 1406 | 127.8 | 8.96 | 157 | 71 | 19 | 0 | 11 |
| 17 | Kered ClassRB, CBNMBHS (Little River) | 1380 | 125.5 | 9.20 | 150 | 94 | 12 | 0 | 11 |
| 18 | Bryce ThompsonQB, RBDutch Fork (Irmo) | 1369 | 97.8 | 8.89 | 154 | 72 | 29 | 2 | 14 |
| 19 | Jarius JeterRB, MLBBroome (Spartanburg) | 1368 | 124.4 | 7.20 | 190 | 0 | 14 | 0 | 11 |
| 20 | Rj EllisRBBHPHS (Honea Path) | 1328 | 120.7 | 5.58 | 238 | 44 | 17 | 5 | 11 |
| 21 | Mykal LeeRB, OLBBarnwell | 1238 | 103.2 | 6.88 | 180 | 47 | 16 | 0 | 12 |
| 22 | Kelvin KirbyRBGaffney | 1233 | 88.1 | 6.78 | 182 | 80 | 9 | 3 | 14 |
| 23 | Marcus RatchfordRB, SBDorman (Roebuck) | 1230 | 82.0 | 7.11 | 173 | 80 | 10 | 1 | 15 |
| 24 | Rj KnowlinAndrews | 1219 | 135.4 | 9.30 | 131 | 75 | 21 | 6 | 9 |
| 25 | Brandon HarveyRB, OLBBarnwell | 1203 | 100.2 | 7.71 | 156 | 77 | 17 | 0 | 12 |
| 26 | Ben BatsonQBDorman (Roebuck) | 1201 | 80.1 | 7.90 | 152 | 58 | 13 | 4 | 15 |
| 27 | Christian GaskinsRB, MLBCA (Myrtle Beach) | 1166 | 129.6 | 6.04 | 193 | 50 | 13 | 1 | 9 |
| 28 | Tevaughn HigginsQB, FSLower Richland (Hopkins) | 1146 | 114.6 | 11.58 | 99 | 0 | 10 | 0 | 10 |
| 29 | Makiah SimmonsRB, LBBBHS (Orangeburg) | 1129 | 125.4 | 8.12 | 139 | 69 | 14 | 0 | 9 |
| 30 | Javorius WilliamsRBDarlington | 1127 | 102.5 | 7.09 | 159 | 71 | 9 | 3 | 11 |
| 31 | Nick CunninghamRBARHS (Summerville) | 1114 | 101.3 | 6.09 | 183 | 75 | 14 | 0 | 11 |
| 32 | Pha'leak BrownRB, CBChester | 1036 | 129.5 | 8.49 | 122 | 23 | 12 | 0 | 8 |
| 33 | John OsborneRB, SSGCHS (Greenwood) | 1016 | 101.6 | 7.53 | 135 | 95 | 13 | 0 | 10 |
| 34 | Jermaine AlstonRB, MLBJames Island (Charleston) | 1000 | 100.0 | 6.25 | 160 | 77 | 11 | 0 | 10 |
| 35 | James McbrideRB, OLBChesterfield | 978 | 81.5 | 5.43 | 180 | 63 | 3 | 2 | 12 |
| 36 | Mario AndersonRBStratford (Goose Creek) | 973 | 121.6 | 7.37 | 132 | 82 | 13 | 1 | 8 |
| 37 | Keyshawn CapersRB, OLBLower Richland (Hopkins) | 933 | 77.8 | 11.81 | 79 | 0 | 7 | 0 | 12 |
| 38 | Zykamren RobinsonRBSpartanburg | 915 | 91.5 | 8.39 | 109 | 0 | 7 | 3 | 10 |
| 39 | Steven SchlosserDB, RBAMHS (North Charleston) | 908 | 113.5 | 5.22 | 174 | 20 | 8 | 1 | 8 |
| 40 | John ErbyQB, WRChester | 906 | 82.4 | 5.63 | 161 | 43 | 16 | 0 | 11 |
| 41 | Michael PipkinRB, FSAndrews | 899 | 89.9 | 6.76 | 133 | 93 | 14 | 2 | 10 |
| 42 | Corey FieldsQBBaptist Hill (Hollywood) | 893 | 74.4 | 8.19 | 109 | 68 | 9 | 1 | 12 |
| 43 | Quincy HillQB, CBSpring Valley (Columbia) | 889 | 74.1 | 6.09 | 146 | 67 | 8 | 8 | 12 |
| 44 | Cavaugio ButlerRB, CBLiberty | 883 | 80.3 | 5.85 | 151 | 60 | 3 | 1 | 11 |
| 45 | Jonathan HenryRB, OLBSumter | 879 | 79.9 | 6.37 | 138 | 62 | 10 | 1 | 11 |
| 46 | Yancey WashingtonQB, FSNorth Charleston | 873 | 97.0 | 8.64 | 101 | 32 | 6 | 0 | 9 |
| 47 | Tyler MitchellRBRidge View (Columbia) | 845 | 76.8 | 6.31 | 134 | 33 | 4 | 2 | 11 |
| 48 | River PenderFB, DTTHA (Ridgeland) | 838 | 76.2 | 9.11 | 92 | 45 | 3 | 0 | 11 |
| 49 | Jaylon MorrisFS, RBSpring Valley (Columbia) | 834 | 69.5 | 11.42 | 73 | 71 | 11 | 0 | 12 |
| 50 | Zykiem JacksonQBSumter | 828 | 92.0 | 6.68 | 124 | 69 | 3 | 1 | 9 |