| 1 | Tyler SmithRB, MLBBarnwell | 2903 | 223.3 | 9.84 | 295 | 0 | 46 | 0 | 13 |
| 2 | Trey ThompsonRB, OLBAndrew Jackson (Kershaw) | 2509 | 179.2 | 7.38 | 340 | 64 | 37 | 3 | 14 |
| 3 | Zay BrownRBCheraw | 1588 | 132.3 | 7.64 | 208 | 0 | 22 | 0 | 12 |
| 4 | Colton LinkRB, CBLandrum | 1267 | 126.7 | 8.99 | 141 | 0 | 18 | 5 | 10 |
| 5 | Vaughn BlueRB, DBOCA (Mt. Pleasant) | 1266 | 158.2 | 6.77 | 187 | 0 | 9 | 0 | 8 |
| 6 | Zion DobsonCB, RBHCHS (Varnville) | 1070 | 89.2 | 5.30 | 202 | 77 | 15 | 0 | 12 |
| 7 | Hernandez O'neal jr.QBKeenan (Columbia) | 983 | 81.9 | 9.83 | 100 | 56 | 8 | 5 | 12 |
| 8 | Maurice BrownQB, WRRHHS (Ridgeland) | 971 | 88.3 | 6.39 | 152 | 26 | 8 | 6 | 11 |
| 9 | Bj MontgomeryRBGCA (West Columbia) | 912 | 101.3 | 8.22 | 111 | 0 | 10 | 0 | 9 |
| 10 | Steven HowardRBKeenan (Columbia) | 868 | 78.9 | 7.36 | 118 | 35 | 14 | 2 | 11 |
| 11 | Braden MashtareRB, OLBLandrum | 814 | 74.0 | 7.27 | 112 | 0 | 9 | 4 | 11 |
| 12 | Jayden LittleRBChesterfield | 813 | 101.6 | 7.39 | 110 | 78 | 16 | 3 | 8 |
| 13 | Tray WilsonRB, FSCentral (Pageland) | 813 | 81.3 | 6.56 | 124 | 63 | 6 | 2 | 10 |
| 14 | Anthony WickerRB, DBMid-Carolina (Prosperity) | 791 | 87.9 | 6.18 | 128 | 60 | 6 | 0 | 9 |
| 15 | Omarion HolmanRBEdisto (Cordova) | 787 | 87.4 | 8.20 | 96 | 97 | 5 | 3 | 9 |
| 16 | Kaegan ChambersQBChesterfield | 758 | 94.8 | 13.30 | 57 | 75 | 6 | 2 | 8 |
| 17 | Maleik WilliamsQB, WRSilver Bluff (Aiken) | 726 | 60.5 | 5.30 | 137 | 44 | 10 | 2 | 12 |
| 18 | Caleb FordRBGCA (West Columbia) | 701 | 77.9 | 7.30 | 96 | 0 | 9 | 2 | 9 |
| 19 | Ashten WilsonRB, MLBCentral (Pageland) | 683 | 62.1 | 6.57 | 104 | 54 | 10 | 2 | 11 |
| 20 | Brayden WilliamsRBSaluda | 604 | 67.1 | 9.15 | 66 | 0 | 7 | 0 | 9 |
| 21 | Edward ReidenbachQB, POCA (Mt. Pleasant) | 595 | 42.5 | 6.26 | 95 | 0 | 19 | 0 | 14 |
| 22 | Elyjah SowellSS, RBAndrew Jackson (Kershaw) | 572 | 52.0 | 9.08 | 63 | 77 | 6 | 0 | 11 |
| 23 | Tucker SwisherRB, DEOCA (Mt. Pleasant) | 547 | 60.8 | 5.31 | 103 | 0 | 8 | 0 | 9 |
| 24 | Kensley CopelandFCHS (Winnsboro) | 533 | 48.5 | 5.22 | 102 | 0 | 5 | 2 | 11 |
| 25 | Wenson SmithRB, LBRHHS (Ridgeland) | 496 | 45.1 | 6.70 | 74 | 35 | 1 | 1 | 11 |
| 26 | Zayvion KingRB, OLBNinety Six | 492 | 61.5 | 6.15 | 80 | 0 | 3 | 1 | 8 |
| 27 | Tyleke MathisATH, ATHSaluda | 472 | 47.2 | 15.23 | 31 | 0 | 8 | 0 | 10 |
| 28 | Aj Jackson,jrFS, WRMid-Carolina (Prosperity) | 416 | 46.2 | 5.27 | 79 | 95 | 4 | 1 | 9 |
| 29 | Amond MyersCB, OLBKingstree | 386 | 38.6 | 6.77 | 57 | 30 | 5 | 0 | 10 |
| 30 | Hammond WrennQBAndrew Jackson (Kershaw) | 378 | 37.8 | 8.79 | 43 | 0 | 3 | 0 | 10 |
| 31 | Daniel JonesRB, OLBSilver Bluff (Aiken) | 365 | 30.4 | 4.40 | 83 | 21 | 4 | 1 | 12 |
| 32 | Braden MitchellQB, MLBNinety Six | 359 | 44.9 | 3.99 | 90 | 0 | 11 | 0 | 8 |
| 33 | Kenmane BrunsonRB, OLBSaluda | 348 | 34.8 | 6.21 | 56 | 0 | 3 | 0 | 10 |
| 34 | Timothy MorrisWR, CBSilver Bluff (Aiken) | 348 | 34.8 | 5.80 | 60 | 23 | 2 | 2 | 10 |
| 35 | Zylan AgnewRBMid-Carolina (Prosperity) | 341 | 37.9 | 8.32 | 41 | 60 | 5 | 5 | 9 |
| 36 | Juwarren JamesRB, OLBEdisto (Cordova) | 328 | 41.0 | 5.05 | 65 | 24 | 4 | 1 | 8 |
| 37 | TyDarion GrierFCHS (Winnsboro) | 320 | 24.6 | 16.00 | 20 | 0 | 4 | 0 | 13 |
| 38 | Steven GadsdenRB, MLBFCHS (Winnsboro) | 314 | 28.5 | 4.24 | 74 | 0 | 3 | 1 | 11 |
| 39 | Blaine RedmondLB, ATHGCA (West Columbia) | 310 | 44.3 | 14.09 | 22 | 0 | 3 | 0 | 7 |
| 40 | Seth RayRB, FSBarnwell | 303 | 23.3 | 8.19 | 37 | 0 | 4 | 0 | 13 |
| 41 | Ja'Shaun DorseyQB, DBKingstree | 294 | 29.4 | 5.16 | 57 | 30 | 2 | 1 | 10 |
| 42 | Zach HagedonDBOCA (Mt. Pleasant) | 270 | 19.3 | 12.86 | 21 | 0 | 2 | 0 | 14 |
| 43 | AJ LindseyRB, MLBLandrum | 270 | 24.5 | 3.91 | 69 | 0 | 4 | 3 | 11 |
| 44 | Jordan PeeplesRB, WRBarnwell | 265 | 22.1 | 6.31 | 42 | 0 | 3 | 0 | 12 |
| 45 | Nigel SolomonWR, CBHCHS (Varnville) | 258 | 23.5 | 7.82 | 33 | 32 | 3 | 0 | 11 |
| 46 | Keith FordSBCheraw | 255 | 21.2 | 3.49 | 73 | 0 | 1 | 0 | 12 |
| 47 | Dreydan DanielWR, CBNinety Six | 244 | 30.5 | 11.09 | 22 | 0 | 2 | 0 | 8 |
| 48 | Nicolas BrownOLB, WRKingstree | 244 | 27.1 | 10.17 | 24 | 52 | 5 | 2 | 9 |
| 49 | Xavier PlowdenizLB, RBRHHS (Ridgeland) | 240 | 24.0 | 4.90 | 49 | 20 | 0 | 0 | 10 |
| 50 | Keaton MurrayWR, TEAMHS (North Charleston) | 236 | 33.7 | 3.15 | 75 | 15 | 2 | 0 | 7 |
