| 1 | Grayson WhiteQB, MLBCamden | 4751 | 316.7 | 3871 | 880 | 0 | 15 |
| 2 | Luke GrayQBPendleton | 3976 | 331.3 | 3811 | 166 | -1 | 12 |
| 3 | Javion MartinFS, WRCrestwood (Sumter) | 2981 | 229.3 | 2554 | 427 | 0 | 13 |
| 4 | Coleman GrayQBChapman (Inman) | 2971 | 247.6 | 2076 | 895 | 0 | 12 |
| 5 | Kolton ChapmanDaniel (Central) | 2863 | 190.9 | 2409 | 454 | 0 | 15 |
| 6 | Colten BagwellQBWren (Piedmont) | 2700 | 225.0 | 1534 | 1166 | 0 | 12 |
| 7 | Trooper FloydQB, FSChester | 2611 | 200.8 | 2060 | 551 | 0 | 13 |
| 8 | Tj MorrisQBWoodruff | 2561 | 232.8 | 2571 | -10 | 0 | 11 |
| 9 | Marquise HendersonRB, CBBHPHS (Honea Path) | 2485 | 177.5 | 0 | 2336 | 149 | 14 |
| 10 | Kamajay Brackett-BrannonQBBroome (Spartanburg) | 2317 | 231.7 | 1206 | 1111 | 0 | 10 |
| 11 | Elijah ColemanRB, DLChester | 2255 | 173.5 | 0 | 1916 | 339 | 13 |
| 12 | Tushawan RichardsonQBClinton | 2216 | 184.7 | 1551 | 665 | 0 | 12 |
| 13 | Markellis "kj" AsburyRB, OLBPSHS (Charleston) | 2175 | 181.2 | 40 | 2017 | 118 | 12 |
| 14 | Julius HippenstielQBHanahan | 2092 | 190.2 | 1957 | 135 | 0 | 11 |
| 15 | Gavin ThomaQBSeneca | 1998 | 199.8 | 2023 | -25 | 0 | 10 |
| 16 | Kevon RiveraRBHanahan | 1997 | 181.5 | 0 | 1994 | 3 | 11 |
| 17 | Samari BondsQBBeaufort | 1819 | 151.6 | 1205 | 614 | 0 | 12 |
| 18 | Tanner LoweryWR, QBWalhalla | 1702 | 189.1 | 1500 | 202 | 0 | 9 |
| 19 | Jaylen McgillRB, MLBBroome (Spartanburg) | 1690 | 169.0 | 0 | 1602 | 88 | 10 |
| 20 | Jaquarius (jah) MayrantWR, CBCamden | 1679 | 111.9 | 0 | 254 | 1425 | 15 |
| 21 | Kari D BennettSB, CBDaniel (Central) | 1678 | 111.9 | 0 | 1508 | 170 | 15 |
| 22 | Noah ThomasQBBHPHS (Honea Path) | 1590 | 113.6 | 1572 | 18 | 0 | 14 |
| 23 | Kory JonesWR, FSPendleton | 1584 | 132.0 | 71 | 4 | 1509 | 12 |
| 24 | Azarian YatesRB, DECrestwood (Sumter) | 1563 | 120.2 | 0 | 1365 | 198 | 13 |
| 25 | Mj SmithQBLower Richland (Hopkins) | 1448 | 144.8 | 1193 | 255 | 0 | 10 |
| 26 | Reese PriceRB, WRWren (Piedmont) | 1426 | 118.8 | 40 | 1274 | 112 | 12 |
| 27 | Jasean BowensCB, WRCA (Greenville) | 1400 | 140.0 | 1280 | 120 | 0 | 10 |
| 28 | Kb HendersonRB, OLBBlue Ridge (Greer) | 1314 | 119.5 | 0 | 1304 | 10 | 11 |
| 29 | Sharod WilliamsHBPSHS (Charleston) | 1278 | 106.5 | 0 | 1270 | 8 | 12 |
| 30 | Aidan HeriotWR, FSCamden | 1259 | 89.9 | 69 | 24 | 1166 | 14 |
| 31 | Lee TurnipseedDaniel (Central) | 1259 | 83.9 | 736 | 506 | 17 | 15 |
| 32 | Jadyn AndrewsRBBeaufort | 1250 | 104.2 | 0 | 1209 | 41 | 12 |
| 33 | Aiden GibsonRBWoodruff | 1170 | 106.4 | 0 | 765 | 405 | 11 |
| 34 | Lamarion PearsonRB, HBLower Richland (Hopkins) | 1167 | 116.7 | 0 | 928 | 239 | 10 |
| 35 | Dylan DaleQB, SSCrescent (Iva) | 1160 | 193.3 | 623 | 474 | 63 | 6 |
| 36 | Abijah WebbWR, CBPendleton | 1146 | 95.5 | 0 | 0 | 1146 | 12 |
| 37 | La’ontray KnoxCB, RBLoris | 1140 | 126.7 | 0 | 944 | 196 | 9 |
| 38 | Kimoray HollandRB, OLBCA (Greenville) | 1140 | 114.0 | 0 | 1042 | 98 | 10 |
| 39 | Shaheem RobbsRBBHPHS (Honea Path) | 1130 | 94.2 | 0 | 1129 | 1 | 12 |
| 40 | Zavean PooleWR, FSSeneca | 1043 | 104.3 | 0 | 0 | 1043 | 10 |
| 41 | Tavien OrellanaQB, CBPSHS (Charleston) | 1004 | 83.7 | 906 | 98 | 0 | 12 |
| 42 | Landon RobinsonRBWalhalla | 1001 | 100.1 | 0 | 972 | 29 | 10 |
| 43 | Tyce GarnerRB, SPalmetto (Williamston) | 982 | 89.3 | 0 | 668 | 314 | 11 |
| 44 | Kadon CrawfordTE, OLBClinton | 974 | 81.2 | 35 | 155 | 784 | 12 |
| 45 | Brooks JanssenQBPalmetto (Williamston) | 973 | 108.1 | 984 | -11 | 0 | 9 |
| 46 | Averee HickmonRBCamden | 969 | 64.6 | 0 | 831 | 138 | 15 |
| 47 | Jeremie RichardsonOLB, WRCrestwood (Sumter) | 962 | 74.0 | 0 | 16 | 946 | 13 |
| 48 | Mathai ScottRBChapman (Inman) | 954 | 79.5 | 0 | 833 | 121 | 12 |
| 49 | Jackson HuffQBLoris | 951 | 95.1 | 921 | 30 | 0 | 10 |
| 50 | Que AlexanderWR, CBBHPHS (Honea Path) | 912 | 65.1 | 0 | 44 | 868 | 14 |
