| 1 | Jason GreenwayRB, DBMitchell | 1483 | 134.8 | 7.27 | 204 | 94 | 11 | 6 | 11 |
| 2 | Jason GreenwayRB, DBMMCHS (CO-OP) (Mitchell) | 1483 | 134.8 | 7.27 | 204 | 94 | 11 | 6 | 11 |
| 3 | Andy KappenmanRB, SSMCCM (CO-OP) (Salem) | 1477 | 134.3 | 8.90 | 166 | 62 | 20 | 0 | 11 |
| 4 | Davonte ClaytateRBWashington (Sioux Falls) | 1437 | 119.8 | 6.28 | 229 | 78 | 19 | 3 | 12 |
| 5 | Logan DolenRBCanton | 1315 | 131.5 | 6.68 | 197 | 65 | 13 | 0 | 10 |
| 6 | Nate RotertRBSpearfish | 1027 | 85.6 | 8.63 | 119 | 89 | 12 | 0 | 12 |
| 7 | Tyson DegrootRBSioux Valley (Volga) | 953 | 119.1 | 7.11 | 134 | 57 | 11 | 0 | 8 |
| 8 | Kyle BertramRBWinner | 936 | 85.1 | 9.96 | 94 | 0 | 9 | 2 | 11 |
| 9 | Luke MarcoeRBSpearfish | 856 | 71.3 | 9.95 | 86 | 99 | 13 | 0 | 12 |
| 10 | Taylor HouchinQBRCCHS (Rapid City) | 835 | 92.8 | 5.57 | 150 | 71 | 13 | 2 | 9 |
| 11 | Taton BoltonRBSTMHS (Rapid City) | 832 | 83.2 | 6.71 | 124 | 62 | 13 | 2 | 10 |
| 12 | Dominic BlindertRB, LBMCCM (CO-OP) (Salem) | 818 | 74.4 | 5.93 | 138 | 37 | 8 | 0 | 11 |
| 13 | Connor FitzsimmonsRBYankton | 790 | 79.0 | 7.45 | 106 | 71 | 11 | 0 | 10 |
| 14 | Ben ConnotRBWinner | 750 | 68.2 | 8.15 | 92 | 0 | 15 | 3 | 11 |
| 15 | D'Andre ForeTB, DBVermillion | 722 | 90.2 | 4.51 | 160 | 70 | 7 | 4 | 8 |
| 16 | Jared McClurg*RBWebster | 715 | 89.4 | 6.11 | 117 | 76 | 6 | 1 | 8 |
| 17 | Caden QuintanillaRBLincoln (Sioux Falls) | 697 | 63.4 | 7.74 | 90 | 50 | 10 | 0 | 11 |
| 18 | Hesston EricksonRBBeresford | 679 | 97.0 | 5.26 | 129 | 27 | 8 | 1 | 7 |
| 19 | Doug StenbergRBTodd County (Mission) | 679 | 67.9 | 5.07 | 134 | 64 | 9 | 6 | 10 |
| 20 | Brady HarklessRBHot Springs | 671 | 74.6 | 5.12 | 131 | 25 | 8 | 0 | 9 |
| 21 | Jake SullivanQBSTMHS (Rapid City) | 627 | 62.7 | 6.60 | 95 | 68 | 6 | 2 | 10 |
| 22 | Jacob PattersonRBFlandreau | 562 | 62.4 | 8.39 | 67 | 96 | 7 | 2 | 9 |
| 23 | David ParsleyRBFlandreau | 536 | 67.0 | 6.87 | 78 | 57 | 6 | 3 | 8 |
| 24 | Kase JacobsRBCanton | 536 | 53.6 | 6.70 | 80 | 42 | 10 | 0 | 10 |
| 25 | Justin GreenwayRB, DBMitchell | 532 | 48.4 | 7.94 | 67 | 69 | 7 | 0 | 11 |
| 26 | Justin GreenwayRB, DBMMCHS (CO-OP) (Mitchell) | 532 | 48.4 | 7.94 | 67 | 69 | 7 | 0 | 11 |
| 27 | Zachery BarberRBDell Rapids | 531 | 106.2 | 10.84 | 49 | 80 | 5 | 0 | 5 |
| 28 | Joe ParsleyQBFlandreau | 531 | 59.0 | 10.62 | 50 | 72 | 10 | 1 | 9 |
| 29 | Austin CalhoonRBWinner | 531 | 48.3 | 6.40 | 83 | 0 | 4 | 2 | 11 |
| 30 | Clyde ColombeRBTodd County (Mission) | 530 | 53.0 | 8.28 | 64 | 65 | 8 | 10 | 10 |
| 31 | Gavin GassmanQB, DBMCCM (CO-OP) (Salem) | 488 | 44.4 | 4.28 | 114 | 32 | 5 | 0 | 11 |
| 32 | Mitchel FosterRBFlandreau | 476 | 52.9 | 9.52 | 50 | 59 | 7 | 0 | 9 |
| 33 | Rush MilneRBMadison | 463 | 57.9 | 5.86 | 79 | 71 | 9 | 1 | 8 |
| 34 | Brent HavlikQB, LBMitchell | 422 | 38.4 | 3.30 | 128 | 37 | 10 | 11 | 11 |
| 35 | Brent HavlikQB, LBMMCHS (CO-OP) (Mitchell) | 422 | 38.4 | 3.30 | 128 | 37 | 10 | 11 | 11 |
| 36 | Jackson TruongRBSTMHS (Rapid City) | 416 | 46.2 | 7.30 | 57 | 30 | 6 | 4 | 9 |
| 37 | Hunter WhiteRBDell Rapids | 378 | 75.6 | 9.45 | 40 | 64 | 2 | 0 | 5 |
| 38 | Kevin DiazRBLincoln (Sioux Falls) | 374 | 34.0 | 5.58 | 67 | 31 | 10 | 3 | 11 |
| 39 | Asher PikulaWRRCCHS (Rapid City) | 351 | 35.1 | 8.78 | 40 | 55 | 2 | 4 | 10 |
| 40 | Channing BarberQBDell Rapids | 343 | 68.6 | 6.60 | 52 | 46 | 4 | 0 | 5 |
| 41 | Cameron ThomasLBWashington (Sioux Falls) | 341 | 28.4 | 9.74 | 35 | 53 | 3 | 3 | 12 |
| 42 | Andy Rithmiller*RBWebster | 319 | 53.2 | 5.23 | 61 | 81 | 3 | 3 | 6 |
| 43 | Evan SchroederRBYankton | 315 | 35.0 | 7.50 | 42 | 30 | 5 | 0 | 9 |
| 44 | Newt JohnsonRBSTMHS (Rapid City) | 313 | 62.6 | 5.30 | 59 | 31 | 4 | 0 | 5 |
| 45 | Trace MeyerFBWinner | 291 | 26.5 | 8.82 | 33 | 0 | 5 | 1 | 11 |
| 46 | Mitchel BrownFBVermillion | 291 | 32.3 | 2.97 | 98 | 26 | 0 | 4 | 9 |
| 47 | Cody MajeresQBCanton | 286 | 31.8 | 6.50 | 44 | 67 | 5 | 0 | 9 |
| 48 | Cole HolzerRBRCCHS (Rapid City) | 280 | 28.0 | 5.38 | 52 | 25 | 1 | 2 | 10 |
| 49 | Austin RicheyFBWinner | 274 | 24.9 | 5.17 | 53 | 0 | 2 | 2 | 11 |
| 50 | Dyllan RathertWRSturgis Brown (Sturgis) | 270 | 54.0 | 3.75 | 72 | 0 | 0 | 3 | 5 |