| 1 | Caden QuintanillaRBLincoln (Sioux Falls) | 1893 | 172.1 | 7.37 | 257 | 80 | 29 | 4 | 11 |
| 2 | Rush MilneRB, DBMadison | 1364 | 124.0 | 6.37 | 214 | 77 | 33 | 3 | 11 |
| 3 | Kenneth MyersRB, SCuster | 913 | 91.3 | 6.34 | 144 | 30 | 10 | 2 | 10 |
| 4 | Blake StoneRB, DBRCCHS (Rapid City) | 869 | 96.6 | 4.62 | 188 | 42 | 9 | 2 | 9 |
| 5 | Luke ReiterLB, RBWashington (Sioux Falls) | 705 | 78.3 | 5.88 | 120 | 45 | 6 | 9 | 9 |
| 6 | Riley ScherrWR, DBSTMHS (Rapid City) | 644 | 58.5 | 7.76 | 83 | 68 | 15 | 1 | 11 |
| 7 | Jace ChristiansenQB, LBFlandreau | 530 | 66.2 | 4.91 | 108 | 36 | 7 | 0 | 8 |
| 8 | Trevor FishRB, LBLead-Deadwood (Lead) | 523 | 65.4 | 4.12 | 127 | 57 | 5 | 2 | 8 |
| 9 | Mitch JohnsonRB, LBMitchell | 520 | 57.8 | 3.82 | 136 | 44 | 4 | 2 | 9 |
| 10 | Alex BakkedahlRB, DBFlandreau | 462 | 57.8 | 5.70 | 81 | 40 | 4 | 0 | 8 |
| 11 | Tim GassmanMCCM (CO-OP) (Salem) | 444 | 63.4 | 7.52 | 59 | 91 | 1 | 0 | 7 |
| 12 | Hayden HallRB, DBSioux Valley (Volga) | 439 | 54.9 | 4.57 | 96 | 50 | 2 | 0 | 8 |
| 13 | Caden SkinnerWR, DBSTMHS (Rapid City) | 416 | 37.8 | 6.82 | 61 | 67 | 9 | 1 | 11 |
| 14 | Tanner WeaverQBSturgis Brown (Sturgis) | 324 | 40.5 | 2.42 | 134 | 60 | 8 | 1 | 8 |
| 15 | Levi DavisRB, LBYankton | 301 | 43.0 | 4.93 | 61 | 40 | 1 | 0 | 7 |
| 16 | Mitch HansenQB, LBMadison | 294 | 32.7 | 6.00 | 49 | 24 | 3 | 1 | 9 |
| 17 | Brock SwartosRB, LBSioux Valley (Volga) | 289 | 36.1 | 5.35 | 54 | 54 | 3 | 2 | 8 |
| 18 | Trevor LundinRB, LBSioux Valley (Volga) | 276 | 39.4 | 4.60 | 60 | 50 | 4 | 3 | 7 |
| 19 | Kanin NelsonQB, LBMitchell | 267 | 29.7 | 2.34 | 114 | 36 | 6 | 4 | 9 |
| 20 | Dan MarletteLBWashington (Sioux Falls) | 265 | 33.1 | 4.42 | 60 | 25 | 4 | 2 | 8 |
| 21 | Matt WagnerRB, LBLincoln (Sioux Falls) | 260 | 23.6 | 8.12 | 32 | 80 | 5 | 0 | 11 |
| 22 | Ty HermanRB, LBTodd County (Mission) | 254 | 28.2 | 4.23 | 60 | 28 | 0 | 5 | 9 |
| 23 | Brodie FrederiksenRB, LBMadison | 247 | 22.5 | 4.94 | 50 | 27 | 4 | 2 | 11 |
| 24 | Jerry KappenmanMCCM (CO-OP) (Salem) | 235 | 39.2 | 3.79 | 62 | 13 | 3 | 0 | 6 |
| 25 | Matt EastmoQB, DBSTMHS (Rapid City) | 233 | 21.2 | 5.06 | 46 | 39 | 0 | 1 | 11 |
| 26 | Layne LucasQB, DBSioux Valley (Volga) | 220 | 27.5 | 5.95 | 37 | 54 | 3 | 4 | 8 |
| 27 | Brenden AmiotteRB, LBSTMHS (Rapid City) | 212 | 30.3 | 5.05 | 42 | 50 | 1 | 1 | 7 |
| 28 | Jacob GilesQB, DBMadison | 207 | 18.8 | 6.47 | 32 | 33 | 3 | 2 | 11 |
| 29 | Landon NeugebauerWR, DBMitchell | 204 | 22.7 | 5.23 | 39 | 24 | 1 | 1 | 9 |
| 30 | Hunter Two eagleRB, LBTodd County (Mission) | 199 | 39.8 | 4.85 | 41 | 38 | 2 | 6 | 5 |
| 31 | Clayton WahlstromTE, LBCuster | 198 | 19.8 | 4.50 | 44 | 18 | 4 | 0 | 10 |
| 32 | Justin MillerWR, QBWashington (Sioux Falls) | 198 | 28.3 | 3.96 | 50 | 21 | 2 | 8 | 7 |
| 33 | Tyler ClevelandMCCM (CO-OP) (Salem) | 191 | 31.8 | 3.60 | 53 | 30 | 3 | 0 | 6 |
| 34 | Connor BurchillQBLincoln (Sioux Falls) | 186 | 18.6 | 4.54 | 41 | 42 | 2 | 7 | 10 |
| 35 | Joe ClairmontRB, DBTodd County (Mission) | 186 | 20.7 | 2.58 | 72 | 20 | 4 | 9 | 9 |
| 36 | Mason HemmerRB, LBMadison | 182 | 22.8 | 4.92 | 37 | 35 | 2 | 1 | 8 |
| 37 | Jeremy LongRB, LBTodd County (Mission) | 182 | 20.2 | 4.33 | 42 | 15 | 3 | 2 | 9 |
| 38 | Ted SlatteryRB, DBFlandreau | 181 | 22.6 | 5.66 | 32 | 65 | 2 | 0 | 8 |
| 39 | Stetson LippertRB, MLBSturgis Brown (Sturgis) | 173 | 21.6 | 2.37 | 73 | 12 | 2 | 2 | 8 |
| 40 | Mato FosterRB, DETodd County (Mission) | 148 | 16.4 | 6.73 | 22 | 39 | 1 | 0 | 9 |
| 41 | Tristan HullihenRB, DBRCCHS (Rapid City) | 145 | 16.1 | 4.39 | 33 | 17 | 0 | 1 | 9 |
| 42 | Logan RaabeLBWashington (Sioux Falls) | 139 | 15.4 | 4.09 | 34 | 36 | 2 | 0 | 9 |
| 43 | Adam BelhajRB, DBLincoln (Sioux Falls) | 135 | 27.0 | 7.50 | 18 | 36 | 0 | 0 | 5 |
| 44 | Isaac SchubertRB, DBMadison | 129 | 11.7 | 5.38 | 24 | 38 | 3 | 0 | 11 |
| 45 | Lucas HeitkampRB, LBLincoln (Sioux Falls) | 127 | 11.5 | 5.52 | 23 | 35 | 2 | 1 | 11 |
| 46 | Tim ParsleyRB, DBFlandreau | 124 | 15.5 | 3.44 | 36 | 23 | 0 | 0 | 8 |
| 47 | Tanner NelsonRB, DBSturgis Brown (Sturgis) | 118 | 14.8 | 2.51 | 47 | 15 | 0 | 0 | 8 |
| 48 | Isiah RoachQB, DBLincoln (Sioux Falls) | 112 | 14.0 | 3.73 | 30 | 23 | 0 | 3 | 8 |
| 49 | Zach DiehlWR, DBSTMHS (Rapid City) | 109 | 13.6 | 12.11 | 9 | 42 | 0 | 0 | 8 |
| 50 | Martin MuellerRB, OLBRCCHS (Rapid City) | 106 | 11.8 | 15.14 | 7 | 48 | 1 | 1 | 9 |