| 1 | Carter DerSarkissianRB, LBBarker/Royalton-Hartland | 1506 | 188.2 | 10.84 | 139 | 88 | 26 | 0 | 8 |
| 2 | Connor McCaffreyRB, FSCGHS (Canisteo) | 1189 | 169.9 | 7.98 | 149 | 80 | 14 | 1 | 7 |
| 3 | James ChaseRB, LBAvon | 1035 | 147.9 | 8.42 | 123 | 0 | 11 | 0 | 7 |
| 4 | Brady McClurgQB, FSLRCM (CO-OP) (Le Roy) | 921 | 115.1 | 7.74 | 119 | 72 | 17 | 2 | 8 |
| 5 | Parker MooreRB, MLBNotre Dame (Batavia) | 904 | 129.1 | 6.07 | 149 | 69 | 6 | 4 | 7 |
| 6 | TRAVIS TOLBERT JR.RB, DBGeneva | 885 | 110.6 | 8.35 | 106 | 75 | 13 | 1 | 8 |
| 7 | Justin MedinaRB, OLBBrighton (Rochester) | 844 | 105.5 | 10.42 | 81 | 51 | 16 | 0 | 8 |
| 8 | Kaliem SmithRB, OLBAI (Rochester) | 832 | 118.9 | 5.99 | 139 | 55 | 8 | 4 | 7 |
| 9 | Zane KropmanRB, OLBPenfield | 801 | 114.4 | 4.80 | 167 | 37 | 5 | 1 | 7 |
| 10 | Jayden NelsonRBIrondequoit (Rochester) | 766 | 109.4 | 7.09 | 108 | 0 | 7 | 0 | 7 |
| 11 | Carson DeRenzoRB, LBClyde-Savannah (Clyde) | 710 | 88.8 | 5.42 | 131 | 49 | 10 | 1 | 8 |
| 12 | Zack RossignolRB, MLBBrighton (Rochester) | 666 | 83.2 | 8.54 | 78 | 58 | 7 | 0 | 8 |
| 13 | Joshua CottonRB, LBEastridge (Rochester) | 656 | 82.0 | 7.13 | 92 | 62 | 8 | 0 | 8 |
| 14 | Elijah TruesdellRB, CBGAHS (Rochester) | 611 | 87.3 | 6.64 | 92 | 47 | 8 | 0 | 7 |
| 15 | Imani Wagstaff JrRB, LBRHHS (Henrietta) | 609 | 87.0 | 6.41 | 95 | 50 | 7 | 1 | 7 |
| 16 | Alex OhlsonOAEHS (CO-OP) (Oakfield) | 605 | 86.4 | 7.38 | 82 | 0 | 7 | 0 | 7 |
| 17 | Khamari EldridgeLB, RBGeneva | 595 | 74.4 | 7.17 | 83 | 83 | 10 | 0 | 8 |
| 18 | Bowerman AaronHB, LBBarker/Royalton-Hartland | 592 | 74.0 | 10.03 | 59 | 53 | 5 | 1 | 8 |
| 19 | Wesley ChildsRB, DEBrockport | 585 | 117.0 | 6.36 | 92 | 27 | 6 | 3 | 5 |
| 20 | James Mobley Jr.RB, LBEWIHS (CO-OP) (Rochester) | 574 | 95.7 | 8.08 | 71 | 34 | 7 | 0 | 6 |
| 21 | Chase AntinoreQB, RBNotre Dame (Batavia) | 571 | 81.6 | 9.21 | 62 | 18 | 8 | 0 | 7 |
| 22 | Ben SantosQB, ATHGeneva | 510 | 63.8 | 8.50 | 60 | 80 | 8 | 4 | 8 |
| 23 | Terrence BarnerCB, RBMonroe (Rochester) | 496 | 99.2 | 12.72 | 39 | 59 | 3 | 0 | 5 |
| 24 | Cole GoetzRB, CBPittsford | 496 | 62.0 | 5.51 | 90 | 60 | 2 | 0 | 8 |
| 25 | Briyceton ThomasRB, OLBUP (Rochester) | 445 | 89.0 | 9.08 | 49 | 0 | 5 | 0 | 5 |
| 26 | Taye BrownQB, DBEWIHS (CO-OP) (Rochester) | 441 | 73.5 | 7.88 | 56 | 59 | 6 | 3 | 6 |
| 27 | Nicolas SalernoRB, LBNewark/Marion (Newark) | 425 | 53.1 | 4.72 | 90 | 56 | 2 | 2 | 8 |
| 28 | Brendan MangoneQB, SSRHHS (Henrietta) | 404 | 50.5 | 11.22 | 36 | 33 | 7 | 0 | 8 |
| 29 | Luke JohnsonRBVictor | 385 | 55.0 | 3.85 | 100 | 0 | 0 | 0 | 7 |
| 30 | Aidan CoulterRB, LBALHS (Allegany) | 384 | 54.9 | 5.82 | 66 | 47 | 1 | 0 | 7 |
| 31 | Roland GoodenoughRB, LBLRCM (CO-OP) (Le Roy) | 381 | 47.6 | 7.33 | 52 | 68 | 2 | 2 | 8 |
| 32 | William FranzHB, DBAttica | 377 | 75.4 | 5.46 | 69 | 29 | 4 | 1 | 5 |
| 33 | Jude ChristRB, LBLRCM (CO-OP) (Le Roy) | 366 | 45.8 | 7.62 | 48 | 33 | 5 | 3 | 8 |
| 34 | Isaiah AlexanderRB, LBLyons/Sodus (Sodus) | 365 | 45.6 | 5.14 | 71 | 27 | 3 | 0 | 8 |
| 35 | Yeriel Diaz-PenaTB, CBYork/Pavilion (Retsof) | 364 | 52.0 | 6.74 | 54 | 75 | 5 | 0 | 7 |
| 36 | Johnny AyersWB, CBYork/Pavilion (Retsof) | 362 | 51.7 | 6.46 | 56 | 90 | 6 | 0 | 7 |
| 37 | Carson ShetlerOAEHS (CO-OP) (Oakfield) | 346 | 49.4 | 6.53 | 53 | 0 | 3 | 0 | 7 |
| 38 | Landen NagelRB, LBAttica | 328 | 54.7 | 4.75 | 69 | 34 | 1 | 1 | 6 |
| 39 | Kellan CampeRB, FSAI (Rochester) | 322 | 107.3 | 5.28 | 61 | 54 | 2 | 0 | 3 |
| 40 | Owen MaedlFB, LBBarker/Royalton-Hartland | 315 | 39.4 | 6.70 | 47 | 16 | 5 | 0 | 8 |
| 41 | Jeff WatersRB, CBBarker/Royalton-Hartland | 314 | 39.2 | 12.56 | 25 | 45 | 1 | 0 | 8 |
| 42 | Kalin WatkinsQB, LBWSHS (Webster) | 313 | 104.3 | 8.03 | 39 | 39 | 6 | 0 | 3 |
| 43 | Kadyn BucknerFS, RBBrighton (Rochester) | 306 | 38.2 | 7.65 | 40 | 53 | 4 | 0 | 8 |
| 44 | Jeremiah DyerRB, LBWSHS (Webster) | 303 | 101.0 | 7.39 | 41 | 80 | 3 | 0 | 3 |
| 45 | Zach BoopRB, LBLRCM (CO-OP) (Le Roy) | 303 | 37.9 | 5.41 | 56 | 20 | 4 | 0 | 8 |
| 46 | Carter AbbateRB, FSVictor | 301 | 43.0 | 5.19 | 58 | 0 | 2 | 0 | 7 |
| 47 | Brailon JohnsonWR, DBEastridge (Rochester) | 296 | 49.3 | 13.46 | 22 | 85 | 2 | 1 | 6 |
| 48 | Eli RicciRB, QBVictor | 267 | 33.4 | 5.80 | 46 | 0 | 6 | 0 | 8 |
| 49 | Ashton ShriverRB, FSClyde-Savannah (Clyde) | 263 | 32.9 | 6.12 | 43 | 24 | 2 | 3 | 8 |
| 50 | Brennen WeberRB, LBLRCM (CO-OP) (Le Roy) | 253 | 31.6 | 9.04 | 28 | 56 | 3 | 0 | 8 |