| 1 | Frank BarnackRB, OLBEden/North Collins (Eden) | 406 | 50.8 | 4.56 | 89 | 49 | 3 | 0 | 8 |
| 2 | Owen KrouseRB, FSEden/North Collins (Eden) | 378 | 47.2 | 4.20 | 90 | 20 | 2 | 0 | 8 |
| 3 | Jarrett EckEden/North Collins (Eden) | 220 | 73.3 | 6.29 | 35 | 53 | 2 | 0 | 3 |
| 4 | Sam SpenceRB, DBEden/North Collins (Eden) | 202 | 28.9 | 3.06 | 66 | 20 | 3 | 0 | 7 |
| 5 | Anthony CummingsFB, ILBEden/North Collins (Eden) | 145 | 18.1 | 4.14 | 35 | 14 | 2 | 0 | 8 |
| 6 | Andy BialyQB, DBEden/North Collins (Eden) | 97 | 12.1 | 3.88 | 25 | 17 | 0 | 0 | 8 |
| 7 | Matt LeeRB, OLBEden/North Collins (Eden) | 37 | 5.3 | 2.06 | 18 | 5 | 0 | 0 | 7 |
| 8 | Zachary SickauFB, DLEden/North Collins (Eden) | 11 | 2.8 | 2.20 | 5 | 6 | 0 | 0 | 4 |
| 9 | Joe LopezRB, DBEden/North Collins (Eden) | 10 | 5.0 | 3.33 | 3 | 6 | 0 | 0 | 2 |
| 10 | Cole SimmonsRB, DBEden/North Collins (Eden) | 2 | 1.0 | 2.00 | 1 | 2 | 0 | 0 | 2 |
| 1 | Ryan MillerRB, CBMGCL (CO-OP) | 2263 | 188.6 | 9.71 | 233 | 63 | 32 | 0 | 12 |
| 2 | Matt Kloc jrRB, CBIroquois (Elma) | 1359 | 151.0 | 5.71 | 238 | 79 | 15 | 0 | 9 |
| 3 | Marshawn GibsonRB, CBCheektowaga | 1302 | 118.4 | 7.32 | 178 | 73 | 18 | 1 | 11 |
| 4 | Grayson TaylorFB, LBCHHS (Cheektowaga) | 1268 | 140.9 | 8.57 | 148 | 84 | 16 | 2 | 9 |
| 5 | Chris WoodardQB, PNorth Tonawanda | 1235 | 176.4 | 11.76 | 105 | 80 | 19 | 2 | 7 |
| 6 | Brett PecoraroRB, LBMedina/Webber (Medina) | 1001 | 111.2 | 8.56 | 117 | 83 | 9 | 5 | 9 |
| 7 | Kyle BurdickRB, LBNewfane | 970 | 107.8 | 5.81 | 167 | 60 | 6 | 0 | 9 |
| 8 | Dominick SniderRB, DBBarker/Royalton-Hartland | 884 | 98.2 | 7.49 | 118 | 77 | 9 | 1 | 9 |
| 9 | Stephen GlinskiQB, LBNichols (Buffalo) | 852 | 106.5 | 6.93 | 123 | 95 | 13 | 0 | 8 |
| 10 | Zacc KinseyRB, CBJamestown | 843 | 70.2 | 7.20 | 117 | 87 | 5 | 2 | 12 |
| 11 | Vincent GregoryRB, LBAmherst Central (Amherst) | 828 | 103.5 | 8.12 | 102 | 95 | 5 | 4 | 8 |
| 12 | Marcus FordRB, MLBMaryvale (Cheektowaga) | 773 | 85.9 | 6.90 | 112 | 65 | 5 | 0 | 9 |
| 13 | Jarod BrandonRB, CBGrand Island | 739 | 92.4 | 4.99 | 148 | 54 | 4 | 0 | 8 |
| 14 | Devan JacksonRB, FSJamestown | 738 | 61.5 | 6.77 | 109 | 62 | 7 | 0 | 12 |
| 15 | Korey AyersRB, OLBClymer/Sherman (Sherman) | 706 | 88.2 | 4.38 | 161 | 0 | 4 | 4 | 8 |
| 16 | Marcus HamptonRB, OLBBMSTPAS (CO-OP) (Buffalo) | 704 | 88.0 | 7.57 | 93 | 67 | 11 | 2 | 8 |
| 17 | Jordan IngersonRB, DBFrewsburg | 671 | 74.6 | 5.16 | 130 | 47 | 9 | 0 | 9 |
| 18 | Kahlil JamesRB, CBLockport | 665 | 83.1 | 6.58 | 101 | 0 | 8 | 3 | 8 |
| 19 | Keyon JohnsonQB, CBMcKinley (Buffalo) | 664 | 83.0 | 10.06 | 66 | 92 | 3 | 6 | 8 |
| 20 | Nikkolas HollandQBJamestown | 600 | 46.2 | 3.95 | 152 | 26 | 16 | 3 | 13 |
| 21 | Lexus PollardDE, FBKennedy (Cheektowaga) | 595 | 66.1 | 4.34 | 137 | 40 | 4 | 1 | 9 |
| 22 | Tyron LawsonRB, CBCheektowaga | 556 | 46.3 | 11.58 | 48 | 98 | 9 | 0 | 12 |
| 23 | Shaolin MccrayRB, CBNiagara Falls | 545 | 109.0 | 7.68 | 71 | 80 | 3 | 0 | 5 |
| 24 | Jermaine HaristonOL, DLCHHS (Cheektowaga) | 529 | 58.8 | 5.75 | 92 | 35 | 7 | 1 | 9 |
| 25 | Stow NathanRB, LBPanama | 503 | 62.9 | 5.59 | 90 | 40 | 3 | 3 | 8 |
| 26 | Kwaine DavisFB, DEMaryvale (Cheektowaga) | 497 | 55.2 | 6.14 | 81 | 78 | 6 | 0 | 9 |
| 27 | Mike HalfertyRB, DEMaryvale (Cheektowaga) | 487 | 54.1 | 6.49 | 75 | 43 | 2 | 0 | 9 |
| 28 | Zak CiezkiQB, SSCheektowaga | 485 | 40.4 | 4.14 | 117 | 38 | 8 | 2 | 12 |
| 29 | Andrew HwangRB, WRWNHS (Williamsville) | 477 | 95.4 | 6.12 | 78 | 38 | 3 | 0 | 5 |
| 30 | Kenneth WilliamsFB, ILBNichols (Buffalo) | 466 | 58.2 | 5.55 | 84 | 57 | 8 | 1 | 8 |
| 31 | Dillon BarrettRB, OLBFrontier (Hamburg) | 447 | 55.9 | 8.28 | 54 | 70 | 5 | 0 | 8 |
| 32 | Mercy Cox-hicksHB, LBNichols (Buffalo) | 420 | 52.5 | 4.56 | 92 | 24 | 2 | 0 | 8 |
| 33 | Matt LanzalacoLB, RBKennedy (Cheektowaga) | 384 | 42.7 | 4.17 | 92 | 29 | 2 | 0 | 9 |
| 34 | Trevor KochRB, OLBFrontier (Hamburg) | 375 | 41.7 | 4.75 | 79 | 30 | 4 | 0 | 9 |
| 35 | Brandon BojanowskiRB, CBMaryvale (Cheektowaga) | 372 | 41.3 | 10.94 | 34 | 72 | 3 | 3 | 9 |
| 36 | Devon JoyRB, DBMedina/Webber (Medina) | 371 | 46.4 | 7.57 | 49 | 45 | 7 | 0 | 8 |
| 37 | Joe DotterweichRB, OLBNorth Tonawanda | 359 | 51.3 | 4.49 | 80 | 26 | 2 | 0 | 7 |
| 38 | Joshua MeadRB, DLBarker/Royalton-Hartland | 359 | 39.9 | 4.08 | 88 | 33 | 3 | 3 | 9 |
| 39 | Anthony SullivanQB, DBCHHS (Cheektowaga) | 353 | 39.2 | 4.58 | 77 | 71 | 3 | 7 | 9 |
| 40 | Lawrence JenkinsRB, CBLake Shore (Angola) | 337 | 56.2 | 5.27 | 64 | 49 | 5 | 0 | 6 |