| 1 | Aaron WahlerRB, LBCHHS (Cheektowaga) | 1929 | 160.8 | 11.55 | 167 | 96 | 31 | 5 | 12 |
| 2 | Javon ThomasRB, RBCHHS (Cheektowaga) | 1561 | 130.1 | 9.46 | 165 | 76 | 18 | 4 | 12 |
| 3 | Derek EcklundRB, LBCCSP (CO-OP) (Clymer) | 1277 | 106.4 | 6.58 | 194 | 65 | 17 | 6 | 12 |
| 4 | Jaden HeersRB, LBNewfane | 1238 | 137.6 | 9.04 | 137 | 95 | 12 | 0 | 9 |
| 5 | Robbie PenhollowFCVHS (CO-OP) (Falconer) | 1094 | 136.8 | 6.55 | 167 | 64 | 15 | 0 | 8 |
| 6 | Djae PerryRB, OLBLJBOMECE (CO-OP) | 1009 | 112.1 | 14.41 | 70 | 69 | 9 | 3 | 9 |
| 7 | Michael BeatmanRB, LBCCSP (CO-OP) (Clymer) | 902 | 69.4 | 8.28 | 109 | 58 | 11 | 3 | 13 |
| 8 | Jordan ParksQB, SBNWHS (Sanborn) | 901 | 112.6 | 10.99 | 82 | 95 | 10 | 0 | 8 |
| 9 | Rashad LawRB, SSMaryvale (Cheektowaga) | 883 | 110.4 | 11.18 | 79 | 85 | 12 | 0 | 8 |
| 10 | John SpeyerRB, OLBWSWHS (West Seneca) | 876 | 97.3 | 7.89 | 111 | 69 | 10 | 1 | 9 |
| 11 | Shaun DolacMLB, RBWSEHS (West Seneca) | 873 | 145.5 | 5.56 | 157 | 41 | 7 | 1 | 6 |
| 12 | Jimmy ScottHBSJCI (Buffalo) | 808 | 89.8 | 7.48 | 108 | 44 | 6 | 1 | 9 |
| 13 | Cory DaySS, WRIroquois (Elma) | 807 | 89.7 | 9.28 | 87 | 74 | 12 | 1 | 9 |
| 14 | Amari GordanRB, FSSJCI (Buffalo) | 733 | 73.3 | 5.82 | 126 | 49 | 6 | 3 | 10 |
| 15 | Dylan MannRBWNHS (Williamsville) | 730 | 121.7 | 5.84 | 125 | 44 | 9 | 0 | 6 |
| 16 | Joel NicholasRBCanisius (Buffalo) | 729 | 72.9 | 7.52 | 97 | 0 | 10 | 4 | 10 |
| 17 | Alex WeakfallDB, QBOlean | 705 | 100.7 | 6.35 | 111 | 0 | 10 | 7 | 7 |
| 18 | Xzavier JanczylikRB, CBSt. Francis (Hamburg) | 700 | 58.3 | 6.80 | 103 | 77 | 7 | 0 | 12 |
| 19 | Semaj ClemonsRB, OLBLJBOMECE (CO-OP) | 688 | 76.4 | 10.42 | 66 | 60 | 6 | 0 | 9 |
| 20 | Brilliance JohnsonRB, DBAlbion | 660 | 73.3 | 7.50 | 88 | 0 | 7 | 0 | 9 |
| 21 | Louis IrizarryRB, DBOrchard Park | 636 | 70.7 | 3.79 | 168 | 0 | 7 | 0 | 9 |
| 22 | Hayden CarderRB, DBFrontier (Hamburg) | 626 | 78.2 | 6.88 | 91 | 68 | 2 | 0 | 8 |
| 23 | Brayden DunlapRB, DBWilson | 622 | 69.1 | 6.16 | 101 | 47 | 6 | 1 | 9 |
| 24 | Nick StottHB, LBNWHS (Sanborn) | 621 | 69.0 | 6.15 | 101 | 30 | 7 | 0 | 9 |
| 25 | Jamall Lewis JrTB, LBCOHHS (Tonawanda) | 620 | 62.0 | 4.34 | 143 | 23 | 6 | 3 | 10 |
| 26 | Brendan GawelTB, CBStarpoint (Lockport) | 615 | 68.3 | 6.68 | 92 | 41 | 10 | 0 | 9 |
| 27 | Brandon BroadnaxATH, DBCOHHS (Tonawanda) | 604 | 60.4 | 5.92 | 102 | 45 | 12 | 0 | 10 |
| 28 | Connor CrabtreeFCVHS (CO-OP) (Falconer) | 600 | 75.0 | 6.06 | 99 | 56 | 6 | 0 | 8 |
| 29 | Peyton OlsonOLB, QBJamestown | 599 | 66.6 | 6.24 | 96 | 52 | 2 | 0 | 9 |
| 30 | David BradshawRB, DBHCTEVTCHSA (CO-OP) | 592 | 74.0 | 5.53 | 107 | 27 | 7 | 0 | 8 |
| 31 | Micah BrownQB, SSSJCI (Buffalo) | 578 | 64.2 | 5.84 | 99 | 35 | 12 | 4 | 9 |
| 32 | Francisco RodriguezSB, RBJamestown | 568 | 63.1 | 5.36 | 106 | 37 | 9 | 0 | 9 |
| 33 | Brandon OrrQB, DBAkron | 565 | 70.6 | 10.09 | 56 | 79 | 5 | 0 | 8 |
| 34 | Zach NortonRB, CBClarence | 562 | 70.2 | 6.61 | 85 | 47 | 5 | 0 | 8 |
| 35 | Ja'qwan ManuelLB, RBSt. Mary's (Lancaster) | 548 | 54.8 | 5.89 | 93 | 71 | 3 | 6 | 10 |
| 36 | Ugene HarrisonRB, LBAlbion | 540 | 67.5 | 7.40 | 73 | 0 | 5 | 1 | 8 |
| 37 | Izaiah RhimQB, DBLyndonville/Webber | 535 | 59.4 | 4.53 | 118 | 22 | 10 | 1 | 9 |
| 38 | Adam MietzWR, DBAkron | 524 | 65.5 | 6.09 | 86 | 81 | 4 | 0 | 8 |
| 39 | Jack PutneyQBClarence | 516 | 86.0 | 6.79 | 76 | 26 | 3 | 0 | 6 |
| 40 | Jon StevensSB, CBClarence | 514 | 64.2 | 8.43 | 61 | 64 | 9 | 1 | 8 |
| 41 | William BraswellRB, DELyndonville/Webber | 484 | 60.5 | 4.70 | 103 | 47 | 3 | 1 | 8 |
| 42 | Justin CampbellRB, OLBLJBOMECE (CO-OP) | 479 | 53.2 | 8.87 | 54 | 45 | 7 | 0 | 9 |
| 43 | Dabeyon HumphreyQB, RBSouth Park (Buffalo) | 477 | 59.6 | 6.72 | 71 | 0 | 4 | 0 | 8 |
| 44 | Jax LightenQB, DBKennedy (Cheektowaga) | 469 | 52.1 | 5.04 | 93 | 0 | 8 | 0 | 9 |
| 45 | Joe JamisonRB, DBCanisius (Buffalo) | 448 | 44.8 | 7.00 | 64 | 0 | 2 | 1 | 10 |
| 46 | Maurice RobertsonQB, CBWSWHS (West Seneca) | 441 | 55.1 | 6.89 | 64 | 56 | 8 | 5 | 8 |
| 47 | Santino AraminiRB, DBKennedy (Cheektowaga) | 430 | 47.8 | 6.42 | 67 | 20 | 7 | 0 | 9 |
| 48 | Blake NolanRB, LBIroquois (Elma) | 427 | 61.0 | 5.62 | 76 | 36 | 3 | 1 | 7 |
| 49 | D'shaun BarefieldRB, OLBAmherst Central (Amherst) | 424 | 60.6 | 4.42 | 96 | 73 | 3 | 1 | 7 |
| 50 | Jay HenleyRB, CBMaryvale (Cheektowaga) | 422 | 52.8 | 8.44 | 50 | 26 | 6 | 0 | 8 |