| 1 | Jaylen ButeraRB, SJamestown | 1165 | 166.4 | 11.54 | 101 | 69 | 19 | 1 | 7 |
| 2 | Thomas SullivanRB, SSOrchard Park | 782 | 111.7 | 4.98 | 157 | 0 | 6 | 0 | 7 |
| 3 | Jayden LassiterFB, OLBPortville | 739 | 184.8 | 10.12 | 73 | 40 | 13 | 1 | 4 |
| 4 | Al McduffieRB, LBLJBOMECE (CO-OP) | 641 | 128.2 | 7.54 | 85 | 53 | 3 | 4 | 5 |
| 5 | Ja'qwan ManuelOLB, RBSt. Mary's (Lancaster) | 617 | 123.4 | 10.12 | 61 | 82 | 4 | 2 | 5 |
| 6 | Jack DlugokinskiRB, SSGrand Island | 546 | 109.2 | 9.41 | 58 | 62 | 7 | 0 | 5 |
| 7 | Nate CummingsB, DBCHHS (Cheektowaga) | 524 | 131.0 | 5.70 | 92 | 30 | 6 | 0 | 4 |
| 8 | Naseem ZieglerRB, SBSJCI (Buffalo) | 508 | 127.0 | 6.20 | 82 | 13 | 4 | 0 | 4 |
| 9 | Blake NolanRB, OLBIroquois (Elma) | 453 | 90.6 | 4.40 | 103 | 47 | 5 | 2 | 5 |
| 10 | Makari InabinettRB, FSBTSJ (Buffalo) | 427 | 106.8 | 7.12 | 60 | 0 | 5 | 0 | 4 |
| 11 | John SwabikATHCCSP (CO-OP) (Clymer) | 423 | 70.5 | 7.98 | 53 | 53 | 5 | 2 | 6 |
| 12 | Ricardo KiddRB, OLBSt. Francis (Hamburg) | 368 | 73.6 | 5.11 | 72 | 17 | 3 | 0 | 5 |
| 13 | Tyler WeigelQB, FSGrand Island | 360 | 60.0 | 5.81 | 62 | 40 | 8 | 0 | 6 |
| 14 | Damien Littleton JrRB, LBCOHHS (Tonawanda) | 316 | 79.0 | 5.64 | 56 | 22 | 3 | 0 | 4 |
| 15 | Jamison PittmanLB, RBOlean | 306 | 51.0 | 7.85 | 39 | 2 | 2 | 1 | 6 |
| 16 | Connor CooperRB, LBCCSP (CO-OP) (Clymer) | 300 | 60.0 | 5.56 | 54 | 23 | 3 | 1 | 5 |
| 17 | Camren WarburtonRBCheektowaga | 299 | 99.7 | 5.07 | 59 | 22 | 1 | 0 | 3 |
| 18 | Landen MowerRB, DBFCVHS (CO-OP) (Falconer) | 292 | 58.4 | 5.31 | 55 | 63 | 2 | 0 | 5 |
| 19 | Tyler BakerQBCanisius (Buffalo) | 259 | 51.8 | 7.85 | 33 | 0 | 5 | 1 | 5 |
| 20 | Railey SilvisDB, QBOlean | 253 | 42.2 | 3.89 | 65 | 22 | 6 | 1 | 6 |
| 21 | Noah AbramRB, DBFCVHS (CO-OP) (Falconer) | 225 | 75.0 | 4.33 | 52 | 18 | 2 | 0 | 3 |
| 22 | Jayden WilsonQBSt. Mary's (Lancaster) | 223 | 44.6 | 8.92 | 25 | 48 | 1 | 3 | 5 |
| 23 | Aiden NennoLB, RBOlean | 216 | 36.0 | 4.80 | 45 | 13 | 0 | 0 | 6 |
| 24 | Demarri JonesLB, WRJamestown | 211 | 42.2 | 8.44 | 25 | 42 | 3 | 0 | 5 |
| 25 | Nick Whitfield jrQBFredonia | 200 | 66.7 | 7.41 | 27 | 70 | 3 | 4 | 3 |
| 26 | Kimal ClarkCB, SSSt. Francis (Hamburg) | 194 | 38.8 | 7.76 | 25 | 75 | 2 | 0 | 5 |
| 27 | Demaris ScarverRB, OLBBTSJ (Buffalo) | 187 | 31.2 | 4.45 | 42 | 0 | 1 | 3 | 6 |
| 28 | Kaedon HolcombRB, DBPortville | 182 | 45.5 | 9.58 | 19 | 12 | 3 | 0 | 4 |
| 29 | Joseph DixonRB, CBCanisius (Buffalo) | 180 | 36.0 | 4.86 | 37 | 0 | 4 | 0 | 5 |
| 30 | Luke AtlasRB, CBWilson | 179 | 29.8 | 2.21 | 81 | 12 | 2 | 0 | 6 |
| 31 | Landen MowerRB, DBFCVHS (CO-OP) (Falconer) | 162 | 40.5 | 5.79 | 28 | 24 | 0 | 0 | 4 |
| 32 | Nick PantusoDB, RBOlean | 162 | 40.5 | 3.60 | 45 | 10 | 1 | 0 | 4 |
| 33 | Matt LotterRB, OLFredonia | 156 | 52.0 | 3.71 | 42 | 12 | 0 | 0 | 3 |
| 34 | Montrice WebsterQB, LBCHHS (Cheektowaga) | 146 | 36.5 | 6.08 | 24 | 14 | 1 | 0 | 4 |
| 35 | Zander KeimRB, TEPortville | 142 | 35.5 | 11.83 | 12 | 0 | 3 | 0 | 4 |
| 36 | Evan WolfeWilson | 141 | 23.5 | 5.04 | 28 | 25 | 1 | 0 | 6 |
| 37 | Luke AtlasRB, CBWilson | 141 | 35.2 | 2.71 | 52 | 21 | 1 | 1 | 4 |
| 38 | Christian LewisRB, LBSt. Mary's (Lancaster) | 135 | 33.8 | 6.75 | 20 | 51 | 1 | 0 | 4 |
| 39 | Jamario ToliverFB, LBLJBOMECE (CO-OP) | 130 | 26.0 | 5.00 | 26 | 19 | 3 | 0 | 5 |
| 40 | Gabe RothRB, LBCCSP (CO-OP) (Clymer) | 128 | 25.6 | 5.82 | 22 | 30 | 1 | 0 | 5 |
| 41 | Fred JohnsonMLB, WRSt. Mary's (Lancaster) | 123 | 24.6 | 8.20 | 15 | 64 | 0 | 1 | 5 |
| 42 | Matthew SamuelRB, LBCOHHS (Tonawanda) | 111 | 27.8 | 2.92 | 38 | 0 | 0 | 0 | 4 |
| 43 | Brendon RamseyRB, LBCCSP (CO-OP) (Clymer) | 111 | 22.2 | 2.92 | 38 | 25 | 3 | 1 | 5 |
| 44 | Antwan HugleyWR, DBCOHHS (Tonawanda) | 109 | 54.5 | 5.19 | 21 | 0 | 2 | 0 | 2 |
| 45 | Derek SearsDB, RBCCSP (CO-OP) (Clymer) | 108 | 18.0 | 6.75 | 16 | 26 | 0 | 2 | 6 |
| 46 | Markell CarterRB, CBJamestown | 98 | 14.0 | 4.90 | 20 | 11 | 1 | 1 | 7 |
| 47 | Cureem HathcockRB, OLBCanisius (Buffalo) | 97 | 19.4 | 5.10 | 19 | 0 | 0 | 0 | 5 |
| 48 | Tyler FigliolaWR, DBGrand Island | 95 | 15.8 | 6.33 | 15 | 25 | 1 | 0 | 6 |
| 49 | Devin AndersonRB, DBJamestown | 93 | 13.3 | 13.29 | 7 | 36 | 0 | 0 | 7 |
| 50 | Peter PicilloRB, DBWEHS (East Amherst) | 85 | 42.5 | 4.72 | 18 | 28 | 0 | 1 | 2 |