| 1 | Dominac AllenRB, DBLJBOMECE (CO-OP) | 2373 | 182.5 | 12.05 | 197 | 95 | 24 | 7 | 13 |
| 2 | Jaylen ButeraRB, FBJamestown | 2341 | 195.1 | 8.64 | 271 | 68 | 36 | 2 | 12 |
| 3 | Christian LewisRB, DLSt. Mary's (Lancaster) | 2141 | 237.9 | 11.83 | 181 | 75 | 23 | 0 | 9 |
| 4 | Trevor BarryRB, OLBIroquois (Elma) | 1344 | 122.2 | 9.46 | 142 | 61 | 18 | 0 | 11 |
| 5 | Ricardo KiddRB, OLBSt. Francis (Hamburg) | 1099 | 99.9 | 5.14 | 214 | 87 | 9 | 0 | 11 |
| 6 | Torey AndersonRB, LBLJBOMECE (CO-OP) | 1002 | 77.1 | 9.36 | 107 | 62 | 7 | 2 | 13 |
| 7 | Camren WarburtonRB, LBCheektowaga | 952 | 105.8 | 5.77 | 165 | 55 | 11 | 0 | 9 |
| 8 | Luke AtlasRB, CBWilson | 722 | 90.2 | 5.82 | 124 | 60 | 8 | 3 | 8 |
| 9 | Jamison PittmanRB, LBOlean | 671 | 74.6 | 5.59 | 120 | 0 | 8 | 1 | 9 |
| 10 | Brody HibbardRB, SSAkron | 656 | 82.0 | 6.02 | 109 | 85 | 9 | 1 | 8 |
| 11 | Trent BurchanowskiRB, LBCCSP (CO-OP) (Clymer) | 628 | 69.8 | 5.92 | 106 | 49 | 13 | 3 | 9 |
| 12 | Ben AndersonMLB, FBJamestown | 623 | 51.9 | 8.65 | 72 | 62 | 5 | 0 | 12 |
| 13 | Chase BramanRB, LBNewfane | 601 | 66.8 | 6.53 | 92 | 45 | 3 | 4 | 9 |
| 14 | Jamario ToliverFB, LBLJBOMECE (CO-OP) | 507 | 46.1 | 7.35 | 69 | 42 | 5 | 0 | 11 |
| 15 | Jayden WilsonQB, FSSt. Mary's (Lancaster) | 501 | 55.7 | 11.93 | 42 | 50 | 8 | 1 | 9 |
| 16 | Travis FryQB, CBAkron | 484 | 53.8 | 5.90 | 82 | 40 | 6 | 1 | 9 |
| 17 | Railey SilvisQB, DBOlean | 448 | 49.8 | 4.82 | 93 | 0 | 2 | 2 | 9 |
| 18 | Tyler BakerQBCanisius (Buffalo) | 431 | 43.1 | 6.07 | 71 | 0 | 7 | 5 | 10 |
| 19 | Radon WrightRB, LBJamestown | 429 | 35.8 | 8.94 | 48 | 53 | 4 | 0 | 12 |
| 20 | Simon BoncaldoRB, LBOrchard Park | 424 | 42.4 | 4.99 | 85 | 0 | 4 | 1 | 10 |
| 21 | Isaiah SimmonsRB, CBWSWHS (West Seneca) | 402 | 100.5 | 5.91 | 68 | 36 | 6 | 2 | 4 |
| 22 | Peter PiccilloRB, DBWEHS (East Amherst) | 398 | 56.9 | 5.10 | 78 | 55 | 0 | 0 | 7 |
| 23 | Cureem HathcockRBCanisius (Buffalo) | 367 | 36.7 | 5.10 | 72 | 0 | 6 | 1 | 10 |
| 24 | Gabe RothRB, LBCCSP (CO-OP) (Clymer) | 359 | 39.9 | 4.72 | 76 | 33 | 3 | 5 | 9 |
| 25 | Larry BurginB, LBCHHS (Cheektowaga) | 335 | 83.8 | 4.86 | 69 | 42 | 2 | 0 | 4 |
| 26 | Trey KleitzQBIroquois (Elma) | 313 | 28.5 | 8.69 | 36 | 33 | 2 | 2 | 11 |
| 27 | Lamar ThomasRB, SSCanisius (Buffalo) | 272 | 27.2 | 8.50 | 32 | 0 | 4 | 0 | 10 |
| 28 | Tom McanultyRB, SSIroquois (Elma) | 248 | 31.0 | 6.53 | 38 | 33 | 2 | 1 | 8 |
| 29 | Marcus JohnsonSt. Mary's (Lancaster) | 229 | 25.4 | 8.81 | 26 | 42 | 4 | 1 | 9 |
| 30 | Chris BergmanWR, OLBAkron | 227 | 25.2 | 6.14 | 37 | 42 | 0 | 0 | 9 |
| 31 | Edgar Key iiiFB, DTLJBOMECE (CO-OP) | 213 | 16.4 | 6.09 | 35 | 33 | 2 | 2 | 13 |
| 32 | Charles LaroseOL, DENewfane | 202 | 22.4 | 6.52 | 31 | 25 | 2 | 2 | 9 |
| 33 | Roderick MillerRB, OLBCanisius (Buffalo) | 197 | 19.7 | 7.04 | 28 | 0 | 3 | 1 | 10 |
| 34 | Kimal ClarkCB, SSSt. Francis (Hamburg) | 190 | 17.3 | 7.92 | 24 | 57 | 2 | 0 | 11 |
| 35 | Lucas FreelandQB, FSWSWHS (West Seneca) | 188 | 37.6 | 4.37 | 43 | 21 | 0 | 0 | 5 |
| 36 | Steve Otremba jr.QBSt. Francis (Hamburg) | 163 | 14.8 | 1.90 | 86 | 35 | 4 | 1 | 11 |
| 37 | Terrence PendergrassRB, OLBSt. Francis (Hamburg) | 144 | 18.0 | 6.86 | 21 | 22 | 3 | 0 | 8 |
| 38 | Chase WilliamsQB, LBCHHS (Cheektowaga) | 138 | 34.5 | 6.27 | 22 | 48 | 1 | 0 | 4 |
| 39 | Jayden LewisWR, DELJBOMECE (CO-OP) | 135 | 10.4 | 22.50 | 6 | 58 | 1 | 1 | 13 |
| 40 | Colton FrerichsQB, MLBWilson | 134 | 19.1 | 4.06 | 33 | 34 | 1 | 2 | 7 |
| 41 | Ryan KrampQB, SBNewfane | 131 | 14.6 | 3.85 | 34 | 14 | 7 | 1 | 9 |
| 42 | Owen DavidsonRB, SKenmore East (Tonawanda) | 124 | 20.7 | 4.96 | 25 | 0 | 1 | 0 | 6 |
| 43 | Blake MartinRB, OLBWilson | 114 | 14.2 | 5.43 | 21 | 20 | 1 | 0 | 8 |
| 44 | Simmarion ThreetRB, CBCOHHS (Tonawanda) | 113 | 18.8 | 3.42 | 33 | 42 | 1 | 1 | 6 |
| 45 | Shamier LandRB, LBLJBOMECE (CO-OP) | 109 | 18.2 | 7.27 | 15 | 25 | 0 | 0 | 6 |
| 46 | Nick PolitowskiRB, LBOrchard Park | 108 | 10.8 | 7.20 | 15 | 0 | 1 | 1 | 10 |
| 47 | Carson PryorRB, DEKenmore East (Tonawanda) | 105 | 13.1 | 2.39 | 44 | 0 | 1 | 0 | 8 |
| 48 | Jimmy ScottSt. Francis (Hamburg) | 98 | 9.8 | 3.50 | 28 | 17 | 6 | 0 | 10 |
| 49 | Zaire LeonardRB, CBCanisius (Buffalo) | 92 | 11.5 | 5.11 | 18 | 0 | 1 | 0 | 8 |
| 50 | Jussean PearsallRB, OLBLJBOMECE (CO-OP) | 90 | 15.0 | 7.50 | 12 | 31 | 0 | 0 | 6 |
