| 1 | Parker HeadleyRB, DBCPA (Walterboro) | 2614 | 201.1 | 7.28 | 359 | 90 | 27 | 4 | 13 |
| 2 | Uriah SingletonTB, SNA (Charleston) | 2612 | 186.6 | 11.16 | 234 | 80 | 41 | 3 | 14 |
| 3 | Quinton SingletonRB, DBSBHS (Summerton) | 2101 | 175.1 | 7.17 | 293 | 83 | 22 | 1 | 12 |
| 4 | Marcus LattimoreRBJames F. Byrnes (Duncan) | 1898 | 237.2 | 7.30 | 260 | 76 | 31 | 0 | 8 |
| 5 | Devin BedenbaughKing Academy (Batesburg) | 1836 | 141.2 | 8.27 | 222 | 0 | 25 | 0 | 13 |
| 6 | Shaun MiddletonRB, LBBaptist Hill (Hollywood) | 1377 | 125.2 | 9.70 | 142 | 80 | 15 | 0 | 11 |
| 7 | Martel JohnsonRBJames Island (Charleston) | 1305 | 100.4 | 5.93 | 220 | 64 | 9 | 7 | 13 |
| 8 | Leonard KennedyRB, DBDreher (Columbia) | 1277 | 116.1 | 7.38 | 173 | 40 | 12 | 0 | 11 |
| 9 | Ranoy HinesRBGoose Creek | 1267 | 105.6 | 5.98 | 212 | 58 | 7 | 2 | 12 |
| 10 | Jerel RichardsQB, DBBible Baptist (Savannah) | 1249 | 124.9 | 8.11 | 154 | 75 | 17 | 8 | 10 |
| 11 | Kadeem BaxterFB, DTSBHS (Summerton) | 1214 | 101.2 | 5.98 | 203 | 84 | 13 | 0 | 12 |
| 12 | Dondre BrownQB, RBHCHS (Varnville) | 1158 | 115.8 | 6.40 | 181 | 0 | 1 | 5 | 10 |
| 13 | Deedward BurrisQBGaffney | 1129 | 80.6 | 4.65 | 243 | 50 | 14 | 6 | 14 |
| 14 | Nick WilliamsonRB, WRStrom Thurmond (Johnston) | 1124 | 102.2 | 5.65 | 199 | 0 | 16 | 0 | 11 |
| 15 | John SharpeRB, LBWalhalla | 1098 | 122.0 | 6.07 | 181 | 76 | 11 | 0 | 9 |
| 16 | Davious ChestnutCBCarvers Bay (Hemingway) | 1078 | 89.8 | 6.42 | 168 | 0 | 0 | 0 | 12 |
| 17 | Donnie MesciaRB, MLBCPA (Walterboro) | 1056 | 81.2 | 6.77 | 156 | 48 | 11 | 4 | 13 |
| 18 | Devante WrightDB, RBLower Richland (Hopkins) | 1055 | 105.5 | 8.44 | 125 | 80 | 8 | 0 | 10 |
| 19 | Julius PendergrassRB, DBChester | 1051 | 95.5 | 6.33 | 166 | 0 | 19 | 0 | 11 |
| 20 | Del'javon SimmonsQB, DBBurke (Charleston) | 1041 | 94.6 | 8.75 | 119 | 65 | 12 | 6 | 11 |
| 21 | Lamichael PushiaRB, DBHemingway | 1034 | 103.4 | 7.83 | 132 | 0 | 11 | 1 | 10 |
| 22 | Brent MinterRB, WRChester | 966 | 96.6 | 5.86 | 165 | 0 | 8 | 0 | 10 |
| 23 | Shane NelsonRB, DBBible Baptist (Savannah) | 953 | 86.6 | 8.74 | 109 | 44 | 8 | 4 | 11 |
| 24 | Tyrone FaireyRB, CBBBHS (Orangeburg) | 946 | 94.6 | 6.62 | 143 | 55 | 10 | 0 | 10 |
| 25 | Joey DeangelisCNHS (Columbia) | 924 | 115.5 | 5.40 | 171 | 51 | 6 | 11 | 8 |
| 26 | Dashawn AllisonRB, DBMcBee | 838 | 104.8 | 5.24 | 160 | 0 | 9 | 0 | 8 |
| 27 | Deantre JohnsonQBMMA (North Charleston) | 814 | 81.4 | 7.61 | 107 | 99 | 13 | 4 | 10 |
| 28 | Virgil SmallsFBGoose Creek | 797 | 72.5 | 5.38 | 148 | 50 | 13 | 0 | 11 |
| 29 | Brian GillardRB, LBMarion | 773 | 85.9 | 11.89 | 65 | 89 | 9 | 1 | 9 |
| 30 | Ashton JohnsonDE, FBSt. Andrew's (Savannah) | 773 | 85.9 | 5.19 | 149 | 32 | 0 | 4 | 9 |
| 31 | Fareal WalkerQB, SCEMHS (Greeleyville) | 771 | 70.1 | 6.07 | 127 | 52 | 13 | 0 | 11 |
| 32 | Raliegh YeldellQBStrom Thurmond (Johnston) | 742 | 61.8 | 5.34 | 139 | 0 | 11 | 0 | 12 |
| 33 | James BishopRBCane Bay (Summerville) | 719 | 71.9 | 4.79 | 150 | 41 | 13 | 1 | 10 |
| 34 | Fritz SimmonsRBCane Bay (Summerville) | 716 | 71.6 | 4.94 | 145 | 38 | 3 | 6 | 10 |
| 35 | Michael HeywardRB, LBBurke (Charleston) | 704 | 58.7 | 5.97 | 118 | 45 | 6 | 0 | 12 |
| 36 | Rondreas TruesdaleRB, LBIndian Land (Fort Mill) | 703 | 78.1 | 7.10 | 99 | 0 | 4 | 0 | 9 |
| 37 | Anthony EnosRBCane Bay (Summerville) | 694 | 57.8 | 4.42 | 157 | 43 | 7 | 0 | 12 |
| 38 | Corinthian WilliamsRB, LBHCHS (Varnville) | 676 | 61.5 | 6.09 | 111 | 0 | 0 | 3 | 11 |
| 39 | Ben FloydKing Academy (Batesburg) | 637 | 49.0 | 5.95 | 107 | 0 | 3 | 0 | 13 |
| 40 | Sheldon Van DykeRB, LBDreher (Columbia) | 623 | 62.3 | 5.32 | 117 | 21 | 8 | 0 | 10 |
| 41 | Josh BlueRB, OLBMCHS (Bennettsville) | 619 | 61.9 | 6.88 | 90 | 0 | 4 | 0 | 10 |
| 42 | Lue ClemmonsRBMarion | 615 | 68.3 | 7.24 | 85 | 75 | 10 | 2 | 9 |
| 43 | Sanbobis McCleodRBNorthwestern (Rock Hill) | 600 | 42.9 | 4.72 | 127 | 40 | 5 | 0 | 14 |
| 44 | Clayton GeathersSCarvers Bay (Hemingway) | 597 | 49.8 | 9.95 | 60 | 0 | 0 | 0 | 12 |
| 45 | Michael SmallsRB, DECross | 590 | 49.2 | 7.76 | 76 | 50 | 5 | 0 | 12 |
| 46 | Julius ClevelandSEMMA (North Charleston) | 549 | 54.9 | 7.32 | 75 | 58 | 2 | 2 | 10 |
| 47 | Kevin SaavedraRB, LBAMHS (North Charleston) | 547 | 54.7 | 6.75 | 81 | 84 | 5 | 0 | 10 |
| 48 | Steven WalkerQB, DBHCHS (Varnville) | 536 | 48.7 | 4.96 | 108 | 0 | 1 | 6 | 11 |
| 49 | Blake HartleyKing Academy (Batesburg) | 530 | 58.9 | 5.15 | 103 | 0 | 1 | 0 | 9 |
| 50 | Wilkins ChrisQBJames Island (Charleston) | 519 | 39.9 | 4.99 | 104 | 47 | 6 | 2 | 13 |
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