| 1 | Justin WorleyQBNorthwestern (Rock Hill) | 4517 | 301.1 | 4366 | 151 | 0 | 15 |
| 2 | Chas DoddQBJames F. Byrnes (Duncan) | 4107 | 513.4 | 4169 | -62 | 0 | 8 |
| 3 | Deedward BurrisQBGaffney | 3772 | 269.4 | 2643 | 1129 | 0 | 14 |
| 4 | Everett GolsonQBMyrtle Beach | 3529 | 235.3 | 3529 | 0 | 0 | 15 |
| 5 | Wilkins ChrisQBJames Island (Charleston) | 3247 | 249.8 | 2728 | 519 | 0 | 13 |
| 6 | Del'javon SimmonsQB, DBBurke (Charleston) | 3152 | 286.5 | 2111 | 1041 | 0 | 11 |
| 7 | Joey CarterQBBen Lippen (Columbia) | 2910 | 242.5 | 2467 | 443 | 0 | 12 |
| 8 | Luke SirgoQB, DBHHCA (Hilton Head Island) | 2799 | 215.3 | 2332 | 467 | 9 | 13 |
| 9 | Parker HeadleyRB, DBCPA (Walterboro) | 2639 | 203.0 | 25 | 2614 | 75 | 13 |
| 10 | Uriah SingletonTB, SNA (Charleston) | 2612 | 186.6 | 0 | 2612 | 169 | 14 |
| 11 | Lee SchurlknightByrnes (Florence) | 2380 | 297.5 | 2168 | 212 | 0 | 8 |
| 12 | Jordan MarshQB, FSCA (North Charleston) | 2286 | 228.6 | 1971 | 315 | 0 | 10 |
| 13 | John WorthyQBLower Richland (Hopkins) | 2129 | 212.9 | 1827 | 302 | 7 | 10 |
| 14 | Quinton SingletonRB, DBSBHS (Summerton) | 2123 | 176.9 | 22 | 2101 | 0 | 12 |
| 15 | Matt LaymanQB, DBHHP (Hilton Head Island) | 1949 | 278.4 | 1836 | 113 | 0 | 7 |
| 16 | Elliott AlfordQBMCHS (Bennettsville) | 1936 | 176.0 | 1439 | 497 | -6 | 11 |
| 17 | Jerel RichardsQB, DBBible Baptist (Savannah) | 1906 | 190.6 | 657 | 1249 | 0 | 10 |
| 18 | Marcus LattimoreRBJames F. Byrnes (Duncan) | 1898 | 237.2 | 0 | 1898 | 753 | 8 |
| 19 | Devin BedenbaughKing Academy (Batesburg) | 1836 | 141.2 | 0 | 1836 | 46 | 13 |
| 20 | Deantre JohnsonQBMMA (North Charleston) | 1692 | 169.2 | 878 | 814 | 0 | 10 |
| 21 | Raliegh YeldellQBStrom Thurmond (Johnston) | 1689 | 140.8 | 947 | 742 | 0 | 12 |
| 22 | Stedman JamesQBBattery Creek (Beaufort) | 1566 | 142.4 | 1621 | -55 | 0 | 11 |
| 23 | Tony McNealQBChester | 1561 | 195.1 | 1511 | 50 | 0 | 8 |
| 24 | Josh CamarireQBIndian Land (Fort Mill) | 1477 | 147.7 | 1336 | 141 | 0 | 10 |
| 25 | Shaun MiddletonRB, LBBaptist Hill (Hollywood) | 1377 | 125.2 | 0 | 1377 | 105 | 11 |
| 26 | Jalen FrazierQB, DBCross | 1346 | 112.2 | 894 | 452 | 0 | 12 |
| 27 | Leonard KennedyRB, DBDreher (Columbia) | 1341 | 121.9 | 64 | 1277 | 58 | 11 |
| 28 | Martel JohnsonRBJames Island (Charleston) | 1305 | 100.4 | 0 | 1305 | 207 | 13 |
| 29 | Ty PowellQBNA (Charleston) | 1299 | 92.8 | 1249 | 50 | 0 | 14 |
| 30 | Fareal WalkerQB, SCEMHS (Greeleyville) | 1285 | 116.8 | 514 | 771 | 9 | 11 |
| 31 | Zach MorrisQB, STimmonsville | 1282 | 106.8 | 1070 | 212 | 0 | 12 |
| 32 | Kadeem BaxterFB, DTSBHS (Summerton) | 1279 | 106.6 | 65 | 1214 | 39 | 12 |
| 33 | Ranoy HinesRBGoose Creek | 1267 | 105.6 | 0 | 1267 | 25 | 12 |
| 34 | Hampton LangstonC, DEKing's Academy (Florence) | 1192 | 132.4 | 1179 | 13 | 0 | 9 |
| 35 | Joel BokelmanWR, QBKing's Academy (Florence) | 1182 | 118.2 | 878 | 304 | 497 | 10 |
| 36 | Dondre BrownQB, RBHCHS (Varnville) | 1158 | 115.8 | 0 | 1158 | 5 | 10 |
| 37 | Nick WilliamsonRB, WRStrom Thurmond (Johnston) | 1124 | 102.2 | 0 | 1124 | 178 | 11 |
| 38 | John SharpeRB, LBWalhalla | 1098 | 122.0 | 0 | 1098 | 129 | 9 |
| 39 | Davious ChestnutCBCarvers Bay (Hemingway) | 1078 | 89.8 | 0 | 1078 | 0 | 12 |
| 40 | Devante WrightDB, RBLower Richland (Hopkins) | 1062 | 106.2 | 7 | 1055 | 246 | 10 |
| 41 | Donnie MesciaRB, MLBCPA (Walterboro) | 1056 | 81.2 | 0 | 1056 | 91 | 13 |
| 42 | Julius PendergrassRB, DBChester | 1051 | 95.5 | 0 | 1051 | 113 | 11 |
| 43 | Lamichael PushiaRB, DBHemingway | 1034 | 103.4 | 0 | 1034 | 0 | 10 |
| 44 | Jenkins ChrisQBLake Marion (Santee) | 1028 | 171.3 | 772 | 256 | 0 | 6 |
| 45 | Thaddeus MorganQB, DBSCHS (Simpsonville) | 1024 | 102.4 | 602 | 422 | 0 | 10 |
| 46 | Justin PressleyQB, DBHemingway | 1021 | 102.1 | 1007 | 14 | 0 | 10 |
| 47 | Steven WalkerQB, DBHCHS (Varnville) | 986 | 89.6 | 450 | 536 | 0 | 11 |
| 48 | Brent MinterRB, WRChester | 966 | 96.6 | 0 | 966 | 299 | 10 |
| 49 | Shane NelsonRB, DBBible Baptist (Savannah) | 953 | 86.6 | 0 | 953 | 38 | 11 |
| 50 | Tyrone FaireyRB, CBBBHS (Orangeburg) | 946 | 94.6 | 0 | 946 | 8 | 10 |
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