| 1 | Elijah KimbleRB, RBCanisius (Buffalo) | 1149 | 143.6 | 9.99 | 115 | 84 | 11 | 0 | 8 |
| 2 | Jimmy ValentineRB, OLBLJBOMECE (CO-OP) | 1040 | 148.6 | 9.46 | 110 | 78 | 14 | 1 | 7 |
| 3 | Bradyn FullerRBSouthwestern (Jamestown) | 987 | 164.5 | 12.99 | 76 | 82 | 11 | 0 | 6 |
| 4 | Jayvon FunderburkRB, DBWNYMCT (CO-OP) (Buffalo) | 875 | 145.8 | 16.83 | 52 | 80 | 11 | 2 | 6 |
| 5 | Sawyer WhitneyRB, LBCCSP (CO-OP) (Clymer) | 822 | 117.4 | 5.63 | 146 | 49 | 6 | 2 | 7 |
| 6 | Dominic Cook Jr.RB, FSSt. Francis (Hamburg) | 748 | 93.5 | 7.56 | 99 | 72 | 11 | 0 | 8 |
| 7 | Brady WaringQB, FSEden/North Collins (Eden) | 746 | 93.2 | 9.82 | 76 | 83 | 8 | 0 | 8 |
| 8 | Jaylin ColemanATH, QBWNYMCT (CO-OP) (Buffalo) | 679 | 97.0 | 12.81 | 53 | 88 | 15 | 0 | 7 |
| 9 | Tyrone Clark Jr.RB, LBSt. Francis (Hamburg) | 670 | 95.7 | 7.79 | 86 | 46 | 10 | 1 | 7 |
| 10 | Joe ReiterRB, LBBarker/Royalton-Hartland | 647 | 92.4 | 8.86 | 73 | 80 | 9 | 0 | 7 |
| 11 | Trent LewisQB, RBSouthwestern (Jamestown) | 637 | 106.2 | 9.95 | 64 | 69 | 11 | 1 | 6 |
| 12 | Thandon BensinkRB, LBCLWB (CO-OP) (Mayville) | 583 | 72.9 | 6.27 | 93 | 41 | 8 | 1 | 8 |
| 13 | Amir HernandezOLB, RBCanisius (Buffalo) | 567 | 70.9 | 8.86 | 64 | 70 | 10 | 2 | 8 |
| 14 | Domonick HirlimanRB, CBOlean | 497 | 71.0 | 5.07 | 98 | 34 | 9 | 0 | 7 |
| 15 | Salvatore BaioCB, RBCOHHS (Tonawanda) | 465 | 77.5 | 6.04 | 77 | 45 | 4 | 0 | 6 |
| 16 | Dontre HamptonRB, LBLJBOMECE (CO-OP) | 461 | 65.9 | 10.72 | 43 | 65 | 3 | 2 | 7 |
| 17 | Dylan SwansonRB, ILBCLVHS (Cattaraugus) | 443 | 110.8 | 7.14 | 62 | 42 | 2 | 1 | 4 |
| 18 | Michael TaylorQBNiagara Falls | 416 | 69.3 | 6.03 | 69 | 23 | 5 | 2 | 6 |
| 19 | Carter DeSarkissianRB, LBBarker/Royalton-Hartland | 412 | 58.9 | 8.08 | 51 | 65 | 3 | 1 | 7 |
| 20 | Javonte SolomonRB, OLBBTSJ (Buffalo) | 402 | 57.4 | 4.10 | 98 | 16 | 2 | 0 | 7 |
| 21 | Allen KingRB, LBWNYMCT (CO-OP) (Buffalo) | 399 | 57.0 | 6.65 | 60 | 35 | 3 | 0 | 7 |
| 22 | Trent ButtlesQB, FSSt. Francis (Hamburg) | 380 | 47.5 | 7.76 | 49 | 85 | 5 | 2 | 8 |
| 23 | Myking DolsonRB, MLBNiagara Falls | 361 | 60.2 | 5.55 | 65 | 56 | 4 | 0 | 6 |
| 24 | David DaltonRB, LBWNYMCT (CO-OP) (Buffalo) | 337 | 48.1 | 8.42 | 40 | 44 | 3 | 0 | 7 |
| 25 | Tysen McCaaQB, FSBarker/Royalton-Hartland | 337 | 48.1 | 8.22 | 41 | 36 | 3 | 1 | 7 |
| 26 | Trey PfeifferRB, CBIroquois (Elma) | 316 | 45.1 | 4.51 | 70 | 39 | 5 | 1 | 7 |
| 27 | Antonio PerryHB, LBCOHHS (Tonawanda) | 311 | 44.4 | 8.89 | 35 | 35 | 1 | 0 | 7 |
| 28 | Thomas Frazier IVQB, LBSt. Mary's (Lancaster) | 302 | 43.1 | 6.04 | 50 | 14 | 6 | 1 | 7 |
| 29 | Davion BlackwellRB, LBWNYMCT (CO-OP) (Buffalo) | 278 | 39.7 | 12.09 | 23 | 47 | 1 | 1 | 7 |
| 30 | Carter BishopWR, CBEden/North Collins (Eden) | 272 | 34.0 | 7.16 | 38 | 51 | 2 | 0 | 8 |
| 31 | Jaden VarnerCB, RBCOHHS (Tonawanda) | 265 | 37.9 | 10.19 | 26 | 85 | 1 | 0 | 7 |
| 32 | Carson WhiteQB, SCCSP (CO-OP) (Clymer) | 264 | 37.7 | 5.28 | 50 | 57 | 3 | 0 | 7 |
| 33 | Owen KicinskiRB, CBSJCI (Buffalo) | 258 | 43.0 | 5.16 | 50 | 13 | 3 | 0 | 6 |
| 34 | Anthony AdinolfeRB, WRBarker/Royalton-Hartland | 254 | 36.3 | 5.18 | 49 | 25 | 3 | 0 | 7 |
| 35 | Brayden GibbsQBCLWB (CO-OP) (Mayville) | 233 | 29.1 | 5.06 | 46 | 20 | 3 | 4 | 8 |
| 36 | Justus KleitzQBIroquois (Elma) | 219 | 31.3 | 6.44 | 34 | 32 | 2 | 0 | 7 |
| 37 | Vincenzo FazzioWR, LBBarker/Royalton-Hartland | 219 | 31.3 | 4.87 | 45 | 25 | 4 | 0 | 7 |
| 38 | Jack EskridgeWR, DBLJBOMECE (CO-OP) | 217 | 36.2 | 12.76 | 17 | 51 | 2 | 0 | 6 |
| 39 | Joe MestQB, FSOlean | 214 | 30.6 | 3.89 | 55 | 70 | 3 | 0 | 7 |
| 40 | Jarod FreemanRB, OLBWSWHS (West Seneca) | 210 | 70.0 | 6.77 | 31 | 36 | 3 | 0 | 3 |
| 41 | Rayshawn RobinsonSouth Park (Buffalo) | 161 | 53.7 | 5.19 | 31 | 10 | 1 | 0 | 3 |
| 42 | Kevin McElwainRB, SSRandolph | 157 | 78.5 | 7.48 | 21 | 0 | 3 | 0 | 2 |
| 43 | Christian FulghamWR, CBBTSJ (Buffalo) | 143 | 20.4 | 8.41 | 17 | 44 | 1 | 0 | 7 |
| 44 | Nick WilliamsWR, FSSt. Francis (Hamburg) | 141 | 17.6 | 6.71 | 21 | 25 | 1 | 0 | 8 |
| 45 | Da'Von MeadowsRB, LBWNYMCT (CO-OP) (Buffalo) | 132 | 33.0 | 7.33 | 18 | 34 | 1 | 0 | 4 |
| 46 | Jaxon MorrisonQB, FSRandolph | 131 | 43.7 | 5.24 | 25 | 0 | 3 | 0 | 3 |
| 47 | Blake BeckerinkWR, LBCCSP (CO-OP) (Clymer) | 127 | 18.1 | 5.52 | 23 | 36 | 2 | 0 | 7 |
| 48 | Marquis HarrisQB, FSBTSJ (Buffalo) | 125 | 20.8 | 3.38 | 37 | 15 | 0 | 0 | 6 |
| 49 | Noah JarnotDL, OLSt. Mary's (Lancaster) | 117 | 16.7 | 7.31 | 16 | 9 | 3 | 0 | 7 |
| 50 | Larry Hardy iiiRB, MLBSt. Francis (Hamburg) | 113 | 14.1 | 3.90 | 29 | 22 | 1 | 0 | 8 |