| 1 | Jimmy ValentineRB, OLBLJBOMECE (CO-OP) | 1754 | 146.2 | 8.52 | 206 | 78 | 23 | 4 | 12 |
| 2 | Elijah KimbleRB, RBCanisius (Buffalo) | 1726 | 156.9 | 8.99 | 192 | 84 | 23 | 0 | 11 |
| 3 | Mac CapenQBNewfane | 1706 | 170.6 | 12.45 | 137 | 96 | 27 | 0 | 10 |
| 4 | Bradyn FullerRBSouthwestern (Jamestown) | 1462 | 162.4 | 12.71 | 115 | 82 | 16 | 0 | 9 |
| 5 | Tyrone Clark Jr.RB, LBSt. Francis (Hamburg) | 1177 | 107.0 | 7.18 | 164 | 75 | 19 | 1 | 11 |
| 6 | Dontre HamptonRB, LBLJBOMECE (CO-OP) | 1055 | 87.9 | 9.59 | 110 | 65 | 9 | 5 | 12 |
| 7 | Sawyer WhitneyRB, LBCCSP (CO-OP) (Clymer) | 1035 | 115.0 | 5.28 | 196 | 49 | 7 | 2 | 9 |
| 8 | Jayvon FunderburkRB, DBWNYMCT (CO-OP) (Buffalo) | 1001 | 125.1 | 14.72 | 68 | 80 | 11 | 2 | 8 |
| 9 | Joe ReiterRB, LBBarker/Royalton-Hartland | 971 | 97.1 | 7.77 | 125 | 80 | 11 | 0 | 10 |
| 10 | Jaylin ColemanATH, QBWNYMCT (CO-OP) (Buffalo) | 960 | 96.0 | 12.31 | 78 | 88 | 18 | 0 | 10 |
| 11 | Thandon BensinkRB, LBCLWB (CO-OP) (Mayville) | 946 | 72.8 | 5.66 | 167 | 41 | 12 | 1 | 13 |
| 12 | Trent LewisQB, RBSouthwestern (Jamestown) | 915 | 101.7 | 9.84 | 93 | 69 | 17 | 1 | 9 |
| 13 | Amir HernandezOLB, RBCanisius (Buffalo) | 873 | 79.4 | 7.86 | 111 | 70 | 13 | 2 | 11 |
| 14 | Brady WaringQB, FSEden/North Collins (Eden) | 867 | 86.7 | 9.42 | 92 | 83 | 12 | 0 | 10 |
| 15 | Dominic Cook Jr.RB, FSSt. Francis (Hamburg) | 748 | 83.1 | 7.56 | 99 | 72 | 11 | 0 | 9 |
| 16 | Trent ButtlesQB, FSSt. Francis (Hamburg) | 657 | 54.8 | 7.14 | 92 | 85 | 9 | 3 | 12 |
| 17 | Domonick HirlimanRB, CBOlean | 643 | 71.4 | 4.95 | 130 | 34 | 10 | 0 | 9 |
| 18 | Carter DeSarkissianRB, LBBarker/Royalton-Hartland | 578 | 57.8 | 7.92 | 73 | 65 | 5 | 1 | 10 |
| 19 | Owen KicinskiRB, CBSJCI (Buffalo) | 552 | 61.3 | 5.31 | 104 | 30 | 9 | 1 | 9 |
| 20 | Tysen McCaaQB, FSBarker/Royalton-Hartland | 533 | 53.3 | 8.60 | 62 | 65 | 6 | 1 | 10 |
| 21 | Antonio PerryHB, LBCOHHS (Tonawanda) | 533 | 59.2 | 7.51 | 71 | 56 | 6 | 0 | 9 |
| 22 | Salvatore BaioCB, RBCOHHS (Tonawanda) | 513 | 64.1 | 5.52 | 93 | 45 | 5 | 0 | 8 |
| 23 | Javonte SolomonRB, OLBBTSJ (Buffalo) | 500 | 55.6 | 3.97 | 126 | 16 | 2 | 0 | 9 |
| 24 | Trey PfeifferRB, CBIroquois (Elma) | 497 | 49.7 | 4.97 | 100 | 39 | 5 | 2 | 10 |
| 25 | Allen KingRB, LBWNYMCT (CO-OP) (Buffalo) | 471 | 47.1 | 5.96 | 79 | 35 | 4 | 0 | 10 |
| 26 | Jarod FreemanRB, OLBWSWHS (West Seneca) | 465 | 58.1 | 5.81 | 80 | 36 | 6 | 0 | 8 |
| 27 | David DaltonRB, LBWNYMCT (CO-OP) (Buffalo) | 462 | 46.2 | 8.72 | 53 | 67 | 6 | 0 | 10 |
| 28 | Dylan SwansonRB, ILBCLVHS (Cattaraugus) | 443 | 110.8 | 7.14 | 62 | 42 | 2 | 1 | 4 |
| 29 | Davion BlackwellRB, LBWNYMCT (CO-OP) (Buffalo) | 426 | 42.6 | 11.51 | 37 | 58 | 2 | 1 | 10 |
| 30 | Justus KleitzQBIroquois (Elma) | 422 | 42.2 | 6.59 | 64 | 32 | 2 | 0 | 10 |
| 31 | Michael TaylorQBNiagara Falls | 416 | 69.3 | 6.03 | 69 | 23 | 5 | 2 | 6 |
| 32 | Brayden GibbsQBCLWB (CO-OP) (Mayville) | 390 | 30.0 | 5.34 | 73 | 20 | 5 | 6 | 13 |
| 33 | Anthony AdinolfeRB, WRBarker/Royalton-Hartland | 384 | 38.4 | 5.82 | 66 | 36 | 4 | 1 | 10 |
| 34 | Vincenzo FazzioWR, LBBarker/Royalton-Hartland | 382 | 38.2 | 6.06 | 63 | 64 | 6 | 1 | 10 |
| 35 | Myking DolsonRB, MLBNiagara Falls | 361 | 60.2 | 5.55 | 65 | 56 | 4 | 0 | 6 |
| 36 | Carter BishopWR, CBEden/North Collins (Eden) | 329 | 32.9 | 5.98 | 55 | 51 | 2 | 0 | 10 |
| 37 | Thomas Frazier IVQB, LBSt. Mary's (Lancaster) | 327 | 40.9 | 6.17 | 53 | 14 | 6 | 1 | 8 |
| 38 | Jack EskridgeWR, DBLJBOMECE (CO-OP) | 326 | 29.6 | 13.58 | 24 | 90 | 3 | 2 | 11 |
| 39 | Carson WhiteQB, SCCSP (CO-OP) (Clymer) | 326 | 36.2 | 5.02 | 65 | 57 | 3 | 0 | 9 |
| 40 | Aidan CoulterOL, LBALHS (Allegany) | 320 | 35.6 | 4.44 | 72 | 0 | 0 | 0 | 9 |
| 41 | Mason AndersonQB, KWSWHS (West Seneca) | 299 | 37.4 | 3.78 | 79 | 26 | 12 | 0 | 8 |
| 42 | Joe MestQB, FSOlean | 273 | 30.3 | 3.84 | 71 | 70 | 6 | 1 | 9 |
| 43 | Jaden VarnerCB, RBCOHHS (Tonawanda) | 265 | 33.1 | 10.19 | 26 | 85 | 1 | 0 | 8 |
| 44 | Tristen GibbsTE, LBCLWB (CO-OP) (Mayville) | 255 | 19.6 | 6.38 | 40 | 20 | 3 | 0 | 13 |
| 45 | Miles TorresRB, DBSouthwestern (Jamestown) | 251 | 31.4 | 8.66 | 29 | 33 | 3 | 0 | 8 |
| 46 | Nolan ZinkRB, DBALHS (Allegany) | 207 | 23.0 | 3.83 | 54 | 0 | 1 | 0 | 9 |
| 47 | Marquis HarrisQB, FSBTSJ (Buffalo) | 175 | 21.9 | 3.57 | 49 | 15 | 0 | 0 | 8 |
| 48 | Christian FulghamWR, CBBTSJ (Buffalo) | 172 | 19.1 | 6.37 | 27 | 44 | 1 | 0 | 9 |
| 49 | Micah AndersonRB, OLBWSWHS (West Seneca) | 169 | 21.1 | 5.45 | 31 | 24 | 1 | 0 | 8 |
| 50 | Nick WilliamsWR, FSSt. Francis (Hamburg) | 158 | 13.2 | 6.32 | 25 | 25 | 1 | 0 | 12 |